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典型文献
NMR assisted studies on the solution structures and functions of antimicrobial peptides
文献摘要:
Microbial resistance has now become a global public health concern,and the spread of multidrug-resistant bacteria also threatens human health.Antimicrobial peptides(AMPs)are a class of small peptides with antibacterial,anti-inflammatory,anti-infective,anti-oxidation,anti-tumor,antiviral functions and immune regulation activities.Due to the small sizes,their structures are easily studied by nuclear magnetic resonance(NMR)techniques.Compared to traditional antibiotics,AMPs have specific antibacterial mecha-nisms,and do not easily result in the production of drug-resistant strains.Thus,the development of new antimicrobial peptides and their wide use instead of chemical anti-biotics are of great significance to human health.In this review,we first summarized the relationship between the structures and functions of antimicrobial peptides.Then,we focused on examples,cathelicidins,a group of cationic antimicrobial peptides with mul-tiple biological activities.Especially,cathelicidin BF30 or BF34,composed of 30 or 34 amino acids,were from the venom glands of the Bungarus fasciatus snake and were considered to be the most active antibacterial peptides among different cathelicidin members.Their solution structures determined by NMR are a-helixes,which are useful in designing new and stable peptides with similar framework,including stapple peptides by inducing chemical modifications in the sidechains of some residues,as well as cyclic peptides by inducing disulfide bond between cysteines in the sequences.
文献关键词:
作者姓名:
Yaying Zhang;Chunyang Cao
作者机构:
College of Chemistry and Materials Science,Shanghai Normal University,100 Guilin Road,Shanghai,200234,China;State Key Laboratory of Bioorganic and Natural Product Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Road,Shanghai,200032,China
引用格式:
[1]Yaying Zhang;Chunyang Cao-.NMR assisted studies on the solution structures and functions of antimicrobial peptides)[J].磁共振快报(英文),2022(04):214-223
A类:
cathelicidins,cathelicidin,BF30,BF34,helixes,stapple,sidechains
B类:
NMR,assisted,studies,solution,structures,functions,antimicrobial,peptides,Microbial,resistance,has,now,become,global,public,health,concern,spread,multidrug,resistant,also,threatens,human,Antimicrobial,AMPs,class,small,antibacterial,inflammatory,infective,oxidation,tumor,antiviral,immune,regulation,activities,Due,sizes,their,easily,studied,by,nuclear,magnetic,resonance,techniques,Compared,traditional,antibiotics,have,specific,mecha,nisms,do,not,result,production,strains,Thus,development,new,wide,instead,chemical,great,significance,In,this,review,first,summarized,relationship,between,Then,focused,examples,group,cationic,tiple,biological,Especially,composed,amino,acids,were,from,venom,glands,Bungarus,fasciatus,snake,considered,most,active,among,different,members,Their,determined,which,useful,designing,stable,similar,framework,including,inducing,modifications,some,residues,well,cyclic,disulfide,bond,cysteines,sequences
AB值:
0.55528
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