典型文献
Old and new damage-associated molecular patterns (DAMPs) in autoimmune diseases
文献摘要：
All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage-associated molecular patterns (DAMPs). In addition to well-characterized DAMPs such as high-mobility group box 1 and adenosine triphosphate, studies on new classes of DAMPs have emerged. Here, we review recent reports of a new class of isoprenoid-derived DAMPs, including farnesyl pyrophosphate and geranylgeranyl pyrophosphate, both of which are pivotal metabolic intermediates of the mevalonate pathway. We also explore the roles of old and new DAMPs in autoimmune diseases that result from dysregulated inflammation. The findings highlight that understanding the functional mechanisms of DAMPs is important to enrich the DAMP family and decipher their immunoregulatory mechanisms to provide new therapeutics for the prevention and treatment of autoimmune diseases.
文献关键词：
autoimmune diseases;damage-associated molecular patterns;farnesyl pyrophosphate;geranylgeranyl diphosphate;mevalonate pathway
中图分类号：
作者姓名：
Kang Na;Liu Xiaohang;Haneef Kabeer;Liu Wanli
作者机构：
School of Life Sciences, Institute for Immunology, MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Key Laboratory for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China;Tsinghua-Peking Center for Life Sciences, Beijing, China
文献出处：
引用格式：
[1]Kang Na;Liu Xiaohang;Haneef Kabeer;Liu Wanli-.Old and new damage-associated molecular patterns (DAMPs) in autoimmune diseases)[J].风湿病与自身免疫（英文）,2022(04):185-197
A类：
B类：
Old,new,associated,molecular,patterns,DAMPs,autoimmune,diseases,All,organisms,living,complex,environments,have,evolved,effective,mechanisms,dynamic,responses,extracellular,stimuli,system,activates,when,damaged,injured,cells,release,In,addition,well,characterized,such,mobility,group,box,adenosine,triphosphate,studies,classes,emerged,Here,review,recent,reports,isoprenoid,derived,including,farnesyl,pyrophosphate,geranylgeranyl,both,which,are,pivotal,metabolic,intermediates,mevalonate,pathway,We,also,explore,roles,old,that,result,from,dysregulated,inflammation,findings,highlight,understanding,functional,important,enrich,family,decipher,their,immunoregulatory,provide,therapeutics,prevention,treatment,diphosphate
AB值：
0.592126
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