典型文献
Current role of surgery for tuberous sclerosis complex-associated epilepsy
文献摘要：
Tuberous sclerosis complex (TSC) is a rare multisystem, autosomal dominant neurocutaneous syndrome in which epilepsy is the most common of several neurological and psychiatric manifestations. Around two thirds of patients develop drug-resistant epilepsy for whom surgical resection of epileptogenic foci is indicated when seizures remain inadequately controlled following trial of two antiseizure medications. The challenge with presurgical and surgical approaches with patients with TSC is overcoming the complexity from the number of tubers and the multiplex epileptogenic network forming the epileptogenic zone. Data suggest that seizure freedom is achieved by 55%-60% of patients, but predictive factors for success have remained elusive, which makes for unconfident selection of surgical candidates. This article presents three different cases as illustrations of the potential challenges faced when assessing the suitability of TSC patients for epilepsy surgery.
文献关键词：
Epilepsy;Everolimus;Imaging;Prognostics;Surgery;Tuberous sclerosis complex (TSC)
中图分类号：
作者姓名：
Specchio Nicola;Pavia Giusy Carfi;de Palma Luca;De Benedictis Alessandro;Pepi Chiara;Conti Marta;Marras Carlo Efisio;Vigevano Federico;Curatolo Paolo
作者机构：
Rare and Complex Epilepsy Unit, Department of Neurosciences, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;Neurosurgery Unit, Department of Neuro-sciences, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;Department of Neurosciences, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, Rome, Italy
文献出处：
引用格式：
[1]Specchio Nicola;Pavia Giusy Carfi;de Palma Luca;De Benedictis Alessandro;Pepi Chiara;Conti Marta;Marras Carlo Efisio;Vigevano Federico;Curatolo Paolo-.Current role of surgery for tuberous sclerosis complex-associated epilepsy)[J].儿科学研究（英文）,2022(01):16-22
A类：
Tuberous,neurocutaneous,epileptogenic,antiseizure,presurgical,unconfident,Everolimus
B类：
Current,role,surgery,tuberous,sclerosis,associated,epilepsy,TSC,rare,multisystem,autosomal,dominant,syndrome,which,most,common,several,neurological,psychiatric,manifestations,Around,thirds,patients,develop,drug,resistant,whom,resection,foci,indicated,when,seizures,inadequately,controlled,following,trial,medications,approaches,overcoming,complexity,from,number,tubers,multiplex,network,forming,zone,Data,suggest,that,freedom,achieved,by,but,predictive,factors,success,have,remained,elusive,makes,selection,candidates,This,article,presents,three,different,cases,illustrations,potential,challenges,faced,assessing,suitability,Epilepsy,Imaging,Prognostics,Surgery
AB值：
0.570881
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
