典型文献
CYP2C19 Genotyping Plus Therapeutic Drug Monitoring Dependent Voriconazole Treatment for Invasive Pulmonary Aspergillosis in a Patient with Liver Failure
文献摘要：
Invasive pulmonary aspergillosis (IPA) is a lethal infectious disease with high mortality in patients with liver failure. Early recognition of the risk factors prompting earlier diagnosis and treatment may improve the outcomes. Voriconazole is recommended as the first-line drug for IPA, but hepatotoxicity limits its use in the context of liver diseases. We report a case of a 63-year-old female who was admitted to the Third Affiliated Hospital of Hebei Medical University due to IPA after glucocorticoid therapy for liver failure. The polymorphism of cytochrome P450 (CYP) isoenzymes showed CYP2C19*1/*2 genotype associated with intermediate metabolism of voriconazole. However, the patient developed side effects such as skin rash, vomiting, hyperbilirubinemia, and alteration of consciousness, even if she received half of the recommended dosage for voriconazole. Therapeutic drug monitoring (TDM) was applied to guide the dosage adjustment of voriconazole in this patient, and consequently, the patient presented a favorable outcome. In conclusion, genotyping screening plus TDM dependent individualized treatment of voriconazole may improve the survival of liver failure patient with IPA.
文献关键词：
Invasive pulmonary aspergillosis;Liver failure;Therapeutic drug monitoring;Voriconazole
中图分类号：
作者姓名：
Shen Chuan;Zhao Qian;Li Ziyue;Wang Wei;Zhao Yalin;Kong Lingya;Xie Jing;Zhao Caiyan
作者机构：
Department of Infectious Disease, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang 050051, China;Clinical Research Center for Infectious Disease of Hebei Province, Shijiazhuang 050051, China;Office of Quality Management and Control in Healthcare, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang 050051, China
文献出处：
引用格式：
[1]Shen Chuan;Zhao Qian;Li Ziyue;Wang Wei;Zhao Yalin;Kong Lingya;Xie Jing;Zhao Caiyan-.CYP2C19 Genotyping Plus Therapeutic Drug Monitoring Dependent Voriconazole Treatment for Invasive Pulmonary Aspergillosis in a Patient with Liver Failure)[J].感染性疾病和免疫（英文）,2022(02):125-128
A类：
Voriconazole,Aspergillosis,voriconazole
B类：
CYP2C19,Genotyping,Plus,Therapeutic,Drug,Monitoring,Dependent,Treatment,Invasive,Pulmonary,Patient,Liver,Failure,pulmonary,aspergillosis,IPA,lethal,infectious,high,mortality,patients,liver,failure,Early,recognition,risk,factors,prompting,earlier,diagnosis,treatment,may,improve,outcomes,recommended,first,line,drug,but,hepatotoxicity,limits,use,context,diseases,We,report,case,year,old,female,who,was,admitted,Third,Affiliated,Hospital,Hebei,Medical,University,due,after,glucocorticoid,therapy,polymorphism,cytochrome,P450,isoenzymes,showed,genotype,associated,intermediate,metabolism,However,developed,side,effects,such,skin,rash,vomiting,hyperbilirubinemia,alteration,consciousness,even,if,she,received,half,dosage,monitoring,TDM,applied,guide,adjustment,this,consequently,presented,favorable,conclusion,genotyping,screening,plus,dependent,individualized,survival
AB值：
0.603137
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
