典型文献
Does airway pressure release ventilation offer new hope for treating acute respiratory distress syndrome?
☆
文献摘要：
Mechanical ventilation (MV) is an essential life support method for patients with acute respiratory distress syndrome (ARDS), which is one of the most common critical illnesses with high mortality in the intensive care unit (ICU). A lung-protective ventilation strategy based on low tidal volume (LTV) has been recommended since a few years; however, as this did not result in a significant decrease of ARDS-related mortality, a more optimal ventilation mode was required. Airway pressure release ventilation (APRV) is an old method defined as a continuous positive airway pressure (CPAP) with a brief intermittent release phase based on the open lung concept; it also perfectly fits the ARDS treatment principle. Despite this, APRV has not been widely used in the past, rather only as a rescue measure for ARDS patients who are difficult to oxygenate. Over recent years, with an increased understanding of the pathophysiology of ARDS, APRV has been reproposed to improve patient prognosis. Nevertheless, this mode is still not routinely used in ARDS patients given its vague definition and complexity. Consequently, in this paper, we summarize the studies that used APRV in ARDS, including adults, children, and animals, to illustrate the settings of parameters, effectiveness in the population, safety (especially in children), incidence, and mechanism of ventilator-induced lung injury (VILI) and effects on extrapulmonary organs. Finally, we found that APRV is likely associated with improvement in ARDS outcomes, and does not increase injury to the lungs and other organs, thereby indicating that personalized APRV settings may be the new hope for ARDS treatment.
文献关键词：
Acute respiratory distress syndrome;Airway pressure release ventilation;Ventilator-induced lung injury;Outcome;Organ protection
中图分类号：
作者姓名：
Cheng Jiangli;Ma Aijia;Dong Meiling;Zhou Yongfang;Wang Bo;Xue Yang;Wang Peng;Yang Jing;Kang Yan
作者机构：
Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
文献出处：
引用格式：
[1]Cheng Jiangli;Ma Aijia;Dong Meiling;Zhou Yongfang;Wang Bo;Xue Yang;Wang Peng;Yang Jing;Kang Yan-.Does airway pressure release ventilation offer new hope for treating acute respiratory distress syndrome?
☆)[J].重症医学（英文）,2022(04):241-248
A类：
oxygenate,reproposed,Ventilator
B类：
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AB值：
0.552684
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