Mawj Mandwie-Laboratory of Cellular and Molecular Neuroscience(LCMN),School of Life Science,Faculty of Science,University of Technology Sydney,Sydney,NSW,Australia;Neural Injury Research Unit,School of Life Science,Faculty of Science,University of Technology Sydney,Sydney,NSW,Australia;School of Medical Sciences(Neuroscience),The University of Sydney,Sydney,NSW,Australia;Department of Biomedical and Biotechnological Sciences,Anatomy,Histology and Movement Sciences Section,School of Medicine,University of Catania,Catania,Italy

Ana R.Costa-Brito;Isabel Gon?alves;Cecília R.A.Santos-CICS-UBI-Health Sciences Research Centre,Universidade da Beira Interior,Covilh?,Portugal;C4-UBI-Cloud Computing Competence Centre,Universidade da Beira Interior,Covilh?,Portugal

Wei-Tao Yan;Yan-Di Yang;Xi-Min Hu;Wen-Ya Ning;Lyu-Shuang Liao;Shuang Lu;Wen-Juan Zhao;Qi Zhang;Kun Xiong-Department of Neurobiology and Human Anatomy,School of Basic Medical Science,Central South University,Changsha,Hunan Province,China;Department of Dermatology,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Department of Human Resources,Third Xiangya Hospital of Central South University,Changsha,Hunan Province,China;Hunan Key Laboratory of Ophthalmology,Changsha,Hunan Province,China

Andrea N.Nortey;Kimberly N.Garces;Abigail S.Hackam-Bascom Palmer Eye Institute,University of Miami Miller School of Medicine,Miami,FL,USA

Siobhán Lawless;Peter J.Bergold-Graduate Program in Neural and Behavioral Sciences,State University of New York-Downstate Health Sciences University,Brooklyn,NY,USA;Department of Physiology and Pharmacology,State University of New York-Downstate Health Sciences University,Brooklyn,NY,USA

Hua Qi;Fan-Nv Xia;Shi Xiao;Juan Li-State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources,College of Plant Protection,South China Agricultural University,Guangzhou 510642,China;Guangdong Laboratory for Lingnan Modern Agriculture,Guangzhou 510642,China;State Key Laboratory of Biocontrol,Guangdong Provincial Key Laboratory of Plant Resources,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China;College of Agronomy,Hunan Agricultural University,Changsha 410128,China

Jie Chen;Tong Wang;Hongbing Xu;Yutong Zhu;Yipeng Du;Beibei Liu;Qian Zhao;Yi Zhang;Lingyan Liu;Ningman Yuan;Jiakun Fang;Yunfei Xie;Shuo Liu;Rongshan Wu;Danqing Shao;Xiaoming Song;Bei He;Bert Brunekreef;Wei Huang-Institute for Risk Assessment Sciences,Utrecht University,P.O.Box 80125,3508 TC Utrecht,The Netherlands;Department of Occupational and Environmental Health,School of Public Health,Peking University,Beijing 100191,China;Peking University Institute of Environmental Medicine,Peking University,Beijing 100191,China;Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education,Peking University,Beijing 100191,China;Department of Respiratory Medicine,Peking University Third Hospital,Beijing 100191,China;Section of Environmental Health,Department of Public Health,University of Copenhagen,Copenhagen,1353 Copenhagen K,Denmark;State Key Laboratory of Environmental Criteria and Risk Assessment,State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals,Chinese Research Academy of Environmental Sciences,Beijing 100012,China

Shalini Nair;Xinguang Chen-Department of Epidemiology,University of Florida,2004 Mowry Road,Gainesville,Florida,32610,USA

Ziyin Zhang;Yue Gao;Zhuo-Xian Meng-Department of Pathology and Pathophysiology and Department of Geriatrics of Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou,China;Key Laboratory of Disease Proteomics of Zhejiang Province,Zhejiang University School of Medicine,Hangzhou,Zhejiang,310058,China;Department of Geriatrics,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,310006,China

Peng Linbo;Zeng Yi;Wu Yuangang;Si Haibo;Shen Bin-Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

Wang Ying;Wang Dan;Yang Li;Zhang Yi-Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China;School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China;Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan 450052, China;State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan 450052, China

Zhou Liya;Lu Hong;Song Zhiqiang;Lyu Bin;Chen Ye;Wang Jiyao;Xia Jun;Zhao Zhan-Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China;Department of Gastroenterology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China;Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310018, China;Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China;Department of Gastroenterology, Fudan University Affiliated Zhongshan Hospital, Shanghai 200032, China;Nottingham Ningbo GRADE Center, Nottingham China Health Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang 315100, China;Academic Unit of Lifespan and Population Health, School of Medicine, The University of Nottingham, Nottingham, UK;Systematic Review Solutions Ltd, Shanghai 201403, China

LIU Hengrui-Biocomma Limited,Shenzhen 518000,China

Guanglei Zhang;P.G. Ranjith;Herbert E.Huppert-Department of Earth Science and Engineering,Imperial College London,London SW7 2BP,UK;Deep Earth Energy Laboratory,Department of Civil Engineering,Monash University,Melbourne,VIC,3800,Australia;Institute of Theoretical Geophysics,King's College,Cambridge CB2 1ST,UK

Hua-Ming Xi;Yi-Jie Ren;Fa Ren;Yu Li;Tian-Yu Feng;Zhi Wang;Ye-Qing Du;Li-Kun Zhang;Jian-Hong Hu-Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest Agriculture and Forestry University,Yangling 712100,China

Kosar Babaei;Mohsen Aziminezhad;Seyedeh Elham Norollahi;Sogand Vahidi;Ali Akbar Samadani-Non-Communicable Disease Research Center,Neyshabur University of Medical Sciences,Neyshabur,Iran;UMR INSERM U 1122,IGE-PCV,Interactions Gène-Environment En Physiopathologie Cardiovascular Université De Lorraine,Nancy,France;Cancer Research Center and Department of Immunology,Semnan University of Medical Sciences,Semnan,Iran;Medical Biology Research Center,Kermanshah University of Medical Sciences,Kermanshah,Iran;Guilan Road Trauma Research Center,Guilan University of Medical Sciences,Rasht,Iran

Xiao-juan Wang;Lin Qi;Ya-fang Cheng;Xue-fei Ji;Tian-yan Chi;Peng Liu;Li-bo Zou-Department of Pharmacology,Shenyang Pharmaceutical University,Shenyang 110016,China

Ke Lin;Na Yang;Wu Luo;Jin-fu Qian;Wei-wei Zhu;Shi-ju Ye;Chen-xin Yuan;Di-yun Xu;Guang Liang;Wei-jian Huang;Pei-ren Shan-Department of Cardiology,The Key Lab of Cardiovascular Disease of Wenzhou,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325035,China;Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China

Lai-liu Luo;Jing-xuan Han;Shou-rong Wu;Vivi Kasim-Key Laboratory for Biorheological Science and Technology of Ministry of Education,College of Bioengineering,Chongqing University,Chongqing 400044,China;The 111 Project Laboratory of Biomechanics and Tissue Repair,College of Bioengineering,Chongqing University,Chongqing 400044,China;State and Local Joint Engineering Laboratory for Vascular Implants,College of Bioengineering,Chongqing University,Chongqing 400044,China

Lu Liang;Wen-yan Xu;Ao Shen;Hui-yu Cen;Zhi-jun Chen;Lin Tan;Ling-min Zhang;Yu Zhang;Ji-jun Fu;Ai-ping Qin;Xue-ping Lei;Song-pei Li;Yu-yan Qin;Jiong-hua Huang;Xi-yong Yu-Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology,the NMPA and State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences and the Fifth Affiliated Hospital,Guangzhou Medical University,Guangzhou 511436,China;Department of Medical Imaging,Affiliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou 510095,China;Department of Cardiovascular Disease,The Third Affiliated Hospital,Guangzhou Medical University,Guangzhou 510150,China