典型文献
An extended analysis of cardiovascular benefits of indoor air filtration intervention among elderly:a randomized crossover trial(Beijing indoor air purifier study,BIAPSY)
文献摘要：
Objective:Evidence on potential cardiovascular benefits of personal-level intervention among the elderly exposed to high levels of particulate matter(PM)remains limited.We aimed to assess improvements in surrogate markers of cardiovascular injury in vulnerable populations at risks by using indoor air filtration units.Methods:We conducted a randomized crossover trial for 2 separate 2-week air filtration interventions in 20 households of patients with stable chronic obstructive pulmonary disease and their partners in the winter of 2013,with concurrent measurements of indoor PM.The changes in biomarkers indicative of cardiac injury,atherosclerosis progression and systemic inflammation following intervention were evaluated using linear mixed-effect models.Results:In the analysis,average levels of indoor PM with aerodynamic diameters＜2.5 μm(PM2.5)decreased significantly by 59.2％(from 59.6 to 24.3 μg/m3,P＜0.001)during the active air filtration.The reduction was accompanied by improvements in levels of high-sensitivity cardiac troponin I by-84.6％(95％confidence interval[CI]:-90.7 to-78.6),growth differentiation factor-15 by-48.1％(95％CI:-31.2 to-25.6),osteoprotegerin by-65.4％(95％CI:-56.5 to-18.7),interleukin-4 by-46.6％(95％CI:-62.3 to-31.0)and myeloperoxidase by-60.3％(95％CI:-83.7 to-3.0),respectively.Conclusion:Indoor air filtration intervention may provide potential cardiovascular benefits in vulnerable popu-lations at risks.
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中图分类号：
作者姓名：
Jie Chen;Tong Wang;Hongbing Xu;Yutong Zhu;Yipeng Du;Beibei Liu;Qian Zhao;Yi Zhang;Lingyan Liu;Ningman Yuan;Jiakun Fang;Yunfei Xie;Shuo Liu;Rongshan Wu;Danqing Shao;Xiaoming Song;Bei He;Bert Brunekreef;Wei Huang
作者机构：
Institute for Risk Assessment Sciences,Utrecht University,P.O.Box 80125,3508 TC Utrecht,The Netherlands;Department of Occupational and Environmental Health,School of Public Health,Peking University,Beijing 100191,China;Peking University Institute of Environmental Medicine,Peking University,Beijing 100191,China;Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education,Peking University,Beijing 100191,China;Department of Respiratory Medicine,Peking University Third Hospital,Beijing 100191,China;Section of Environmental Health,Department of Public Health,University of Copenhagen,Copenhagen,1353 Copenhagen K,Denmark;State Key Laboratory of Environmental Criteria and Risk Assessment,State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals,Chinese Research Academy of Environmental Sciences,Beijing 100012,China
文献出处：
引用格式：
[1]Jie Chen;Tong Wang;Hongbing Xu;Yutong Zhu;Yipeng Du;Beibei Liu;Qian Zhao;Yi Zhang;Lingyan Liu;Ningman Yuan;Jiakun Fang;Yunfei Xie;Shuo Liu;Rongshan Wu;Danqing Shao;Xiaoming Song;Bei He;Bert Brunekreef;Wei Huang-.An extended analysis of cardiovascular benefits of indoor air filtration intervention among elderly:a randomized crossover trial(Beijing indoor air purifier study,BIAPSY))[J].全球健康杂志（英文）,2022(01):30-34
A类：
purifier,BIAPSY
B类：
An,extended,analysis,cardiovascular,benefits,indoor,air,filtration,among,elderly,randomized,crossover,trial,Beijing,study,Objective,Evidence,potential,personal,exposed,high,levels,particulate,matter,remains,limited,We,aimed,assess,improvements,surrogate,injury,vulnerable,populations,risks,by,using,units,Methods,conducted,separate,week,interventions,households,patients,stable,chronic,obstructive,pulmonary,disease,their,partners,winter,concurrent,measurements,changes,biomarkers,indicative,cardiac,atherosclerosis,progression,systemic,inflammation,following,were,evaluated,linear,mixed,effect,models,Results,average,aerodynamic,diameters,PM2,decreased,significantly,from,during,active,reduction,was,accompanied,sensitivity,troponin,confidence,interval,growth,differentiation,osteoprotegerin,interleukin,myeloperoxidase,respectively,Conclusion,Indoor,may,provide
AB值：
0.551178
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