典型文献
A novel simple traumatic brain injury mouse model
文献摘要：
Background::Traumatic brain injury, one of the leading causes of death in adults under 40 years of age in the world, is frequently caused by mechanical shock, resulting in diffuse neuronal damage and long-term cognitive dysfunction. Many existing TBI animal models revival with expensive equipment or special room are needed or the processes of operations are complex and not easy to be widely used. Therefore, a simpler TBI model needs to be designed.Methods::Our TBI model is an innovation of the modeling method through air guns shutting rubber bullets. A core facet is the application of our designed rubber bullet impact device. It could focus the hitting power to the fixed site of the brain, thus triggering a mild closed head injury. Moreover, the degree of damage can be adjusted by the times of shots.Results::Our model induced blood-brain barrier leakage and diffused neuronal damage. Besides, it led to an increased level of Tau phosphorylation and resulted in cognitive dysfunction within several weeks post-injury.Conclusion::Our TBI model is not only simple and time-saving but also can simulate mild brain injuries in clinical. It is suitable for exploring pathobiological mechanisms as well as a screening of potential therapies for TBI.
文献关键词：
Traumatic brain injury;Blood-brain barrier;Rubber bullet impact model;Cognitive dysfunction;Tau phosphorylation
中图分类号：
作者姓名：
Chen Chen;Hou Jiawei;Lu Junfeng;Zhu Zeyu;Yang Yang;Peng Weijia;Pi Rongbiao
作者机构：
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;School of Medicine, Sun Yat-Sen University, 132# Waihuandong Road, High Education Mega Center, Guangzhou 510006, P. R. China;International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangzhou, Guangzhou, China
文献出处：
引用格式：
[1]Chen Chen;Hou Jiawei;Lu Junfeng;Zhu Zeyu;Yang Yang;Peng Weijia;Pi Rongbiao-.A novel simple traumatic brain injury mouse model)[J].中华神经外科杂志（英文）,2022(03):151-159
A类：
pathobiological
B类：
novel,traumatic,brain,injury,mouse,Background,Traumatic,one,leading,causes,death,adults,under,years,world,frequently,caused,by,mechanical,shock,resulting,neuronal,damage,long,term,cognitive,dysfunction,Many,existing,TBI,animal,models,revival,expensive,equipment,special,room,are,needed,processes,operations,complex,not,easy,widely,Therefore,simpler,needs,designed,Methods,Our,innovation,modeling,method,through,air,guns,shutting,rubber,bullets,core,facet,application,our,impact,device,It,could,focus,hitting,power,fixed,site,thus,triggering,mild,closed,head,Moreover,degree,can,adjusted,times,shots,Results,induced,blood,barrier,leakage,diffused,Besides,led,increased,level,Tau,phosphorylation,resulted,within,several,weeks,post,Conclusion,only,saving,but,also,simulate,injuries,clinical,suitable,exploring,mechanisms,well,screening,potential,therapies,Blood,Rubber,Cognitive
AB值：
0.616822
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
