Ning Zhang;Xishan Hao-Translational Cancer Research Center,Peking University,Peking University First Hospital,Beijing 100034,China;Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin,Tianjin's Clinical Research Center for Cancer,Tianjin 300060,China

Dahui Qin-Moffitt Cancer Center,Tampa,FL 33612-9416,USA

Yan Zeng;Yutian Zou;Guanfeng Gao;Shaoquan Zheng;Song Wu;Xiaoming Xie;Hailin Tang-Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China

Wenhui Wang;Li Wang;Junjun She;Jun Zhu-Department of Genetics and Genomic Sciences,Icahn School of Medicine at Mount Sinai,New York,NY 10029,USA;Sema4,a Mount Sinai venture,Stamford,CT 06902,USA;First Affiliate Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Tisch Cancer Institute,Icahn School of Medicine at Mount Sinai,New York,NY 10029,USA

Jiali Dong;Yuan Li;Huiwen Xiao;Ming Cui;Saijun Fan-Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China;Department of Microbiology,College of Life Sciences,Nankai University,Tianjin 300071,China

Xi Cheng;Wensi Zhao;Mengdi Zhu;Bo Wang;Xuege Wang;Xiaoyun Yang;Yuqi Huang;Minjia Tan;Jing Li-Department of Bioinformatics and Biostatistics,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China;The Chemical Proteomics Center and State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Key Laboratory of Tissue Microenvironment and Tumor,Shanghai Institute of Nutrition and Health,Shanghai Institutes for Biological Sciences,University of Chinese Academy of Sciences,Chinese Academy of Sciences(CAS),Shanghai 200031,China

Zhiyong Liu;Yanan Pang;Yin Jia;Qin Qin;Rui Wang;Wei Li;Jie Jing;Haidong Liu;Shanrong Liu-Department of Laboratory Diagnostics,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;Department of Gastroenterology and Hepatology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;Shanghai Institute of Pancreatic Diseases,Shanghai 200433,China;Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers,Fudan University,Shanghai 200433 China;Department of General Surgery,Changzheng Hospital,Second Military Medical University,Shanghai 200433,China;Shanghai Fourth People's Hospital,Tongji University School of Medicine,Shanghai 200081,China

Haixia Shan;Bo Wang;Xiaodong Zhang;Hui Song;Xi Li;Yongxin Zou;Baichun Jiang;Huili Hu;Hao Dou;Changshun Shao;Lifen Gao;Chunhong Ma;Xiaoyun Yang;Xiaohong Liang;Yaoqin Gong-Key Laboratory for Experimental Teratology of the Ministry of Education,Key Laboratory of Infection and Immunity of Shandong Province and Department of Immunology,School of Basic Medical Sciences,Shandong University,Jinan 250012,China;Department of Laboratory Diagnosis,Cangzhou Combination of Traditional Chinese and Western Medicine Hospital of Hebei Province,Cangzhou 061000,China;Division of Gastroenterology and Hepatology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Institute of Digestive Disease,Shanghai 200120,China;Ministry of Education Key Laboratory of Experimental Teratology and Institute of Molecular Medicine and Genetics,School of Basic Medical Sciences,Shandong University,Jinan 250012,China;Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong,Jinan 250012,China;Department of Gastroenterology,Qilu Hospital,Shandong University,Jinan 250012,China

Yuchen Guo;Yangyang Zhou;Wenxin Qin-State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China

Qian Hao;Xiang Zhou-Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China;Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Key Laboratory of Breast Cancer in Shanghai,Fudan University Shanghai Cancer Center,Fudan University,Shanghai 200032,China;Shanghai Key Laboratory of Medical Epigenetics,International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology),Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China

Sha Li;Jinyi Liu;Xiangjin Zheng;Liwen Ren;Yihui Yang;Wan Li;Weiqi Fu;Jinhua Wang;Guanhua Du-The State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Beijing 100050,China;Key Laboratory of Drug Target Research and Drug Screen,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050,China

Yufei Jiang;Huiyun Yuan;Zhuoying Li;Xiaowei Ji;Qiuming Shen;Jiayi Tuo;Jinghao Bi;Honglan Li;Yongbing Xiang-State Key Laboratory of Oncogene and Related Genes&Department of Epidemiology,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China;Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

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