典型文献
Examining heterogeneity of stromal cells in tumor microenvironment based on pan-cancer single-cell RNA sequencing data
文献摘要：
Tumor tissues contain both tumor and non-tumor cells, which include infiltrated immune cells and stromal cells, collectively called the tumor microenvironment (TME). Single-cell RNA sequencing (scRNAseq) enables the examination of heterogeneity of tumor cells and TME. In this review, we examined scRNAseq datasets for multiple cancer types and evaluated the heterogeneity of major cell type composition in different cancer types. We further showed that endothelial cells and fibroblasts/myofibroblasts in different cancer types can be classified into common subtypes, and the subtype composition is clearly associated with cancer characteristic and therapy response.
文献关键词：
中图分类号：
作者姓名：
Wenhui Wang;Li Wang;Junjun She;Jun Zhu
作者机构：
Department of Genetics and Genomic Sciences,Icahn School of Medicine at Mount Sinai,New York,NY 10029,USA;Sema4,a Mount Sinai venture,Stamford,CT 06902,USA;First Affiliate Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Tisch Cancer Institute,Icahn School of Medicine at Mount Sinai,New York,NY 10029,USA
文献出处：
引用格式：
[1]Wenhui Wang;Li Wang;Junjun She;Jun Zhu-.Examining heterogeneity of stromal cells in tumor microenvironment based on pan-cancer single-cell RNA sequencing data)[J].癌症生物学与医学（英文版）,2022(01):30-42
A类：
scRNAseq
B类：
Examining,heterogeneity,stromal,cells,tumor,microenvironment,pan,cancer,single,sequencing,Tumor,tissues,contain,both,which,include,infiltrated,immune,collectively,called,TME,Single,enables,examination,In,this,review,examined,datasets,multiple,evaluated,major,composition,different,We,further,showed,that,endothelial,myofibroblasts,be,classified,into,common,subtypes,clearly,associated,characteristic,therapy,response
AB值：
0.526859
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