典型文献
Acupotomy inhibits aberrant formation of subchondral bone through regulating osteoprotegerin/receptor activator of nuclear factor-KB ligand pathway in rabbits with knee osteoarthritis induced by modified Videman method
文献摘要：
OBJECTIVE:To investigate the effects of acupotomy on inhibiting abnormal formation of subchondral bone in rabbits with knee osteoarthritis(KOA).METHODS:A total of 24 New Zealand rabbits were randomly divided into four groups of 6 rabbits each[control,model,electroacupuncture(EA)and acupotomy].Eighteen KOA model rabbits were established using a modified Videman method.Rabbits in EA and acupotomy groups received the intervention for 3 weeks.Then,the cartilage and subchondral bone unit were obtained and the histomorphological changes were recorded.Osteo-protegerin(OPG)and receptor activator of nuclear factor-KB ligand(RANKL)in subchondral bone were evaluated by Western blotting,real-time polymerase chain reaction and immunohistochemistry.RESULTS:Compared with the model group,both the acupotomy and EA groups showed a significant decrease in the Lequesne index(both P＜0.01)and Mankin score
文献关键词：
中图分类号：
作者姓名：
QIN Luxue;GUO Changqing;ZHAO Ruili;WANG Tong;WANG Junmei;GUO Yan;ZHANG Wei;HU Tingyao;CHEN Xilin;ZHANG Qian;ZHANG Dian;XU Yue
作者机构：
School of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China;the First People's Hospital of Dongcheng District,Beijing 100050,China;Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;the Third Affiliated Hospital of Beijing Universality of Chinese Medicine,Beijing 100029,China
文献出处：
引用格式：
[1]QIN Luxue;GUO Changqing;ZHAO Ruili;WANG Tong;WANG Junmei;GUO Yan;ZHANG Wei;HU Tingyao;CHEN Xilin;ZHANG Qian;ZHANG Dian;XU Yue-.Acupotomy inhibits aberrant formation of subchondral bone through regulating osteoprotegerin/receptor activator of nuclear factor-KB ligand pathway in rabbits with knee osteoarthritis induced by modified Videman method)[J].中医杂志（英文版）,2022(03):389-399
A类：
Acupotomy,Osteo,protegerin
B类：
inhibits,aberrant,formation,subchondral,bone,through,regulating,osteoprotegerin,receptor,activator,nuclear,KB,ligand,pathway,rabbits,knee,osteoarthritis,induced,by,modified,Videman,method,OBJECTIVE,To,investigate,effects,acupotomy,inhibiting,abnormal,KOA,METHODS,total,New,Zealand,were,randomly,divided,into,four,groups,each,control,model,electroacupuncture,EA,Eighteen,established,using,Rabbits,received,intervention,weeks,Then,cartilage,unit,obtained,histomorphological,changes,recorded,OPG,RANKL,evaluated,blotting,real,polymerase,chain,reaction,immunohistochemistry,RESULTS,Compared,both,showed,significant,decrease,Lequesne,Mankin,score
AB值：
0.554794
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
