典型文献
Tumor microenvironment in lung cancer-derived brain metastasis
文献摘要：
Brain metastasis (BM) is the leading cause of mortality in lung cancer patients. The process of BM (from initial primary tumor development, migration and intravasation, dissemination and survival in the bloodstream, extravasation, to colonization and growth to metastases) is a complex process for which few tumor cells complete the entire process. Recent research on BM of lung cancer has recently stressed the essential role of tumor microenvironment (TME) in assisting tumor cells in the completion of each BM step. This review summarizes recent studies regarding the effects of TME on tumor cells in the entire process of BM derived from lung cancer. The identification of vulnerable targets in the TME and their prospects to provide novel therapeutic opportunities are also discussed.
文献关键词：
Lung cancer;Brain metastasis;Tumor microenvironment
中图分类号：
作者姓名：
Liu Wenwen;Powell Charles A;Wang Qi
作者机构：
Translational Research Center for Lung Cancer, The Second Hospital, Dalian Medical University, Dalian, Liaoning 116023, China;Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA;Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, Liaoning 116023, China
文献出处：
引用格式：
[1]Liu Wenwen;Powell Charles A;Wang Qi-.Tumor microenvironment in lung cancer-derived brain metastasis)[J].中华医学杂志（英文版）,2022(15):1781-1791
A类：
intravasation
B类：
Tumor,microenvironment,lung,cancer,derived,brain,metastasis,Brain,BM,leading,cause,mortality,patients,process,from,initial,primary,tumor,development,migration,dissemination,survival,bloodstream,extravasation,colonization,growth,metastases,complex,which,few,cells,complete,entire,Recent,research,has,recently,stressed,essential,role,TME,assisting,completion,each,step,This,review,summarizes,studies,regarding,effects,identification,vulnerable,targets,their,prospects,provide,novel,therapeutic,opportunities,are,also,discussed,Lung
AB值：
0.568465
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