Background Probiotic supplementation has been used to alleviate abdominal pain in children and adolescents with irritable bowel syndrome(IBS),but the evidence is not compelling.Thus,a systematic review and meta-analysis of randomized clinical trials(RCTs)were performed to investigate the effects of probiotic supplementation on abdominal pain in pediatric patients with IBS.Methods PubMed/MEDLINE,Web of Science,Scopus,Cochrane Library,and Embase were the available databases searched to find relevant randomized clinical trials up to April 2021.The effect size was expressed as weighted mean difference(WMD)and 95％confidence interval(CI).Results Seven RCTs with 441 participants were included,from which the meta-analysis demonstrated that probiotic sup-plementation has a significant effect on reducing abdominal pain in pediatric patients with IBS(WMD=-2.36;95％CI-4.12 to-0.60;P=0.009).Although our study involved children and adolescents(≤18 years),the effects of probiotic supplementation seem to be more potent in patients under 10 years old(WMD=-2.55;95％CI-2.84 to-2.27)compared to patients aged 10-18 years(WMD=-1.70;95％CI-2.18 to-1.22).The length of supplementation longer than four weeks was more effective(WMD=-2.43;95％CI-2.76 to-2.09).Conclusion Probiotic supplementation can reduce abdominal pain in pediatric patients with IBS.

Somayeh Fatahi;Amirhossein Hosseini;Mohammad Hassan Sohouli;Aliakbar Sayyari;Katayoun Khatami;Zahra Fazeli Farsani;Hamzeh Amiri;Naghi Dara;Ivan G.O.de Souza;Heitor O.Santos

Pediatric Gastroenterology,Hepatology,and Nutrition Research Center,Research Institute for Children's Health,Shahid Beheshti University of Medical Sciences,Tehran,Iran;Student Research Committee,Faculty of Public Health Branch,Iran University of Medical Sciences,Tehran,Iran;Student Research Committee,Department of Clinical Nutrition and Dietetics,Faculty of Nutrition and Food Technology,Shahid Beheshti University of Medical Sciences,Tehran,Iran;School of Health Sciences,Universidade Salvador(UNIFACS),Salvador,Bahia,Brazil;School of Medicine,Federal University of Uberlandia(UFU),Uberlandia,Minas Gerais,Brazil

世界儿科杂志（英文版）

[1]Somayeh Fatahi;Amirhossein Hosseini;Mohammad Hassan Sohouli;Aliakbar Sayyari;Katayoun Khatami;Zahra Fazeli Farsani;Hamzeh Amiri;Naghi Dara;Ivan G.O.de Souza;Heitor O.Santos-.Effects of probiotic supplementation on abdominal pain severity in pediatric patients with irritable bowel syndrome:a systematic review and meta-analysis of randomized clinical trials)[J].世界儿科杂志（英文版）,2022(05):320-332

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