典型文献
Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice
文献摘要：
Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however,the underlying molecular mechanism remains largely unknown.MSX1 is an anteriorly expressed transcription repressor required for palate development.Here,we investigate the role of Msx1 in regional patterning of the secondary palate.The Wnt1-Cre-mediated expression of Msx1(RosaMsx 1Wnt1-Cre)throughout the palatal mesenchyme leads to cleft palate in mice,associated with aberrant cell proliferation and cell death.Osteogenic patterning of the hard palate in RosaMsx1Wnt1-Cre mice is severely impaired,as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7.Overexpression and knockout of Msx1 in mice show that the transcription repressor pro-motes the expression of the anterior palate-specific Alx1 but represses the expression of the medial-posterior palate genes Barx1,Meox2,and Tbx22.Furthermore,Tbx22 constitutes a direct Msx1 target gene in the secondary palate,suggesting that Msx1 can directly repress the expression of medial-posterior specific genes.Finally,we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development.Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate.
文献关键词：
中图分类号：
作者姓名：
Shicheng Zhu;Hanjing Song;Liangjun Zhong;Suman Huo;Yukun Fang;Wanxin Zhao;Xueqin Yang;Zhong-Min Dai;Rui He;Mengsheng Qiu;Zunyi Zhang;Xiao-Jing Zhu
作者机构：
Institute of Life Sciences,College of Life and Environmental Sciences,Key Laboratory of Mammalian Organogenesis and Regeneration,Hangzhou Normal University,Hangzhou,Zhejiang 311121,China;The Affiliated Hospital,Hangzhou Normal University,Hangzhou,Zhejiang 310015,China
文献出处：
引用格式：
[1]Shicheng Zhu;Hanjing Song;Liangjun Zhong;Suman Huo;Yukun Fang;Wanxin Zhao;Xueqin Yang;Zhong-Min Dai;Rui He;Mengsheng Qiu;Zunyi Zhang;Xiao-Jing Zhu-.Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice)[J].遗传学报,2022(01):63-73
A类：
MSX1,RosaMsx,1Wnt1,mesenchyme,RosaMsx1Wnt1,Sp7,Alx1,Barx1,Meox2,Tbx22
B类：
Essential,role,regulating,posterior,patterning,secondary,palate,mice,Development,displays,molecular,heterogeneity,along,axis,however,underlying,mechanism,remains,largely,unknown,anteriorly,expressed,transcription,repressor,required,development,Here,investigate,regional,Cre,mediated,throughout,palatal,leads,cleft,associated,aberrant,proliferation,death,Osteogenic,hard,severely,impaired,revealed,by,marked,reduction,palatine,bone,formation,decreased,osteogenic,regulator,Overexpression,knockout,show,that,motes,specific,but,represses,medial,genes,Furthermore,constitutes,target,suggesting,can,directly,Finally,determine,downstream,mesenchymal,cells,participates,regulation,Our,findings,unveil,novel,growth
AB值：
0.382429
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
