典型文献
Dancing on Ropes-Enantioselective Functionalization of Preformed Four-Membered Carbocycles
文献摘要：
Cyclobutane derivatives have been recognized as useful structural motifs in organic synthesis and drug design.With the revival of photochemistry,the enantioselective synthesis of cyclobutane derivatives using[2+2]-cycloadditions has garnered numerous attentions.On the other hand,enantioselec-tive functionalization of preformed four-membered carbocycles is emerging as an important complementary approach to access chiral cyclobutane de-rivatives with versatile structural patterns.Herein,we summarize recent advances in this field from 2012.To avoid undesired C—C bond cleavage driv-en by strain-releasing,it is crucial to choose compatible methods for enantioselective functionalization and meanwhile preserving intact four-membered ring skeleton.Guided by calculated hydrogenation enthalpies,which are used to evaluate the strain energy of indicated C—C bond,a clear picture of the developed methodologies on functionalization of four-membered carbocycles combining the strain energy and enhanced reactivity is presented.
文献关键词：
中图分类号：
作者姓名：
Jun Chen;Qiang Zhou;Huayi Fang;Ping Lu
作者机构：
Research Center for Molecular Recognition and Synthesis,Department of Chemistry,Fudan University,220 Handan Lu,Shanghai 200433,China;School of Materials Science and Engineering,Tianjin Key Lab for Rare Earth Materials and Applications,Nankai University,38 Tongyan Road,Tianjin 300350,China
文献出处：
引用格式：
[1]Jun Chen;Qiang Zhou;Huayi Fang;Ping Lu-.Dancing on Ropes-Enantioselective Functionalization of Preformed Four-Membered Carbocycles)[J].中国化学（英文版）,2022(11):1346-1358
A类：
Ropes,Preformed,Membered,Carbocycles,Cyclobutane,cyclobutane,enantioselec,carbocycles
B类：
Dancing,Enantioselective,Functionalization,Four,derivatives,have,been,recognized,useful,structural,motifs,organic,synthesis,drug,design,With,revival,photochemistry,enantioselective,using,2+2,cycloadditions,has,garnered,numerous,attentions,On,other,hand,functionalization,preformed,four,membered,emerging,important,complementary,approach,access,chiral,versatile,patterns,Herein,we,summarize,recent,advances,this,field,from,To,avoid,undesired,bond,cleavage,driv,by,strain,releasing,crucial,choose,compatible,methods,meanwhile,preserving,intact,ring,skeleton,Guided,calculated,hydrogenation,enthalpies,which,are,used,evaluate,energy,indicated,clear,picture,developed,methodologies,combining,enhanced,reactivity,presented
AB值：
0.617482
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