典型文献
Glycoenzyme Tool Development:Principles,Screening Methods,and Recent Advances
文献摘要：
To elucidate the relationship between carbohydrate structure and its biological function,glycoenzyme tools are widely applied in a variety of physio-logical and pathological scenarios.Intricate adjustment via glycoenzyme engineering improved the catalytic efficiency,extended the repertoire of accessible catalytic reactions,and tailored novel substrate specificities.In this review,we introduce the principles of glycoenzyme engineering and summarize the recent advances in the rational design and directed evolution of these enzymes,with an emphasis on screening methods in directed evolution.We also excerpt novel detection methods in glycobiology that can be adapted for the development of next-generation glycoenzyme tools.
文献关键词：
中图分类号：
作者姓名：
Tongxiao Cui;Yi Man;Feifei Wang;Shuyang Bi;Liang Lin;Ran Xie
作者机构：
State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Chemistry and Biomedicine Innovation Center(ChemBIC),Nanjing University,Nanjing,Jiagsu 210023,China;State Key Laboratory of Bio-organic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Shanghai 200032,China
文献出处：
引用格式：
[1]Tongxiao Cui;Yi Man;Feifei Wang;Shuyang Bi;Liang Lin;Ran Xie-.Glycoenzyme Tool Development:Principles,Screening Methods,and Recent Advances)[J].中国化学（英文版）,2022(06):746-758
A类：
Glycoenzyme,glycoenzyme,Intricate,excerpt,glycobiology
B类：
Tool,Development,Principles,Screening,Methods,Recent,Advances,elucidate,relationship,between,carbohydrate,structure,its,biological,function,tools,are,widely,applied,variety,physio,pathological,scenarios,adjustment,via,engineering,improved,catalytic,efficiency,extended,repertoire,accessible,reactions,tailored,novel,substrate,specificities,this,review,introduce,principles,summarize,recent,advances,rational,design,directed,evolution,these,enzymes,emphasis,screening,methods,We,also,detection,that,can,adapted,development,next,generation
AB值：
0.614542
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