Objective:To explore the protective effect and potential mechanisms of danshen root(Salvia miltiorrhiza Bge.,S.miltiorrhiza)and its extracts for the treatment of diabetic nephropathy(DN).Methods:Preclinical studies of S.miltiorrhiza and its extracts on DN were systematically searched in nine databases.The primary outcomes were blood glucose,kidney function,proteinuria,and renal histopa-thology.The secondary outcomes included the related mechanisms.The methodological quality of an-imal studies was assessed based on the risk of bias tool of the Systematic Review Centre for Laboratory Animal Experimentation(SYRCLE)for animal studies.Meta-analysis was performed using R software(version 4.1.2).Results:Twenty-nine animal experimental studies that met the eligibility criteria were included in this study.Compared to the control group,S.miltiorrhiza reduced the serum creatinine,blood urea nitrogen,24-h urine protein,24-h urine albumin,blood glucose,and kidney index(kidney weight/body weight),and alleviated renal pathological damage.In terms of the mechanism of action,compared to the control group,S.miltiorrhiza reduced the levels of transforming growth factor β1,collagen IV,malondialdehyde,tumor necrosis factor a,interleukin-6,and monocyte/macrophage(ED-1),and increased the levels of superoxide dismutase,glutathione peroxidase,nuclear factor E2-related factor 2,and heme oxygenase-1.Conclusion:The existing evidence shows that S.miltiorrhiza has beneficial effects on the animal model of DN,and its mechanism is mainly related to improving kidney fibrosis,oxidative stress,and inflammatory response.

Tingting Jiao;Yunhua Liu;Mei Han;Sitong Wang;Xinjiang Zhang;Xinxue Zhang;Zongjiang Zhao

School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing,102488,China;Centre for Evidence-Based Chinese Medicine,Beijing University of Chinese Medicine,Beijing,102488,China

中医科学杂志（英文）

[1]Tingting Jiao;Yunhua Liu;Mei Han;Sitong Wang;Xinjiang Zhang;Xinxue Zhang;Zongjiang Zhao-.Protective effect and possible mechanisms of Salvia miltiorrhiza Bge.for the treatment of diabetic nephropathy:A systematic review and meta-analysis of animal studies)[J].中医科学杂志（英文）,2022(04):351-364

danshen,histopa,thology

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