典型文献
Identification of egg protein-derived peptides as xanthine oxidase inhibitors: virtual hydrolysis, molecular docking, and in vitro activity evaluation
文献摘要：
The purpose of this study was to screen the xanthine oxidase (XO) inhibitory peptides from egg white proteins through virtual hydrolysis, in vitro activity validation, and molecular docking. The results demonstrated that tripeptide EEK from ovalbumin exhibited potent XO inhibitory activity with an IC50 value of 141 μmol/L. The molecular docking results showed that tripeptide EEK bound with the active center of XO via 3 carbon hydrogen bond interactions, 2 salt bridges, 5 conventional hydrogen bond interactions, and 4 attractive charge interactions. The residues Glu802, Phe1009, and Arg880 may play key roles in the XO catalytic reaction. Especially, the key intermolecular forces of inhibiting XO activity may be special type of hydrogen bonds including carbon hydrogen bond interactions and attraction charge interactions. The novel tripeptide EEK is potential candidates for controlling hyperuricemia.
文献关键词：
中图分类号：
作者姓名：
Zhipeng Yu;Yaxin Cao;Ruotong Kan;Huizhuo Ji;Wenzhu Zhao;Sijia Wu;Jingbo Liu;David Shiuan
作者机构：
School of Food Science and Engineering,Hainan University,Haikou 570228,China;College of Food Science and Engineering,Bohai University,Jinzhou 121013,China;Lab of Nutrition and Functional Food,Jilin University,Changchun 130062,China;Institute of Drug Discovery Technology,Ningbo University,Ningbo 315211,China
文献出处：
引用格式：
[1]Zhipeng Yu;Yaxin Cao;Ruotong Kan;Huizhuo Ji;Wenzhu Zhao;Sijia Wu;Jingbo Liu;David Shiuan-.Identification of egg protein-derived peptides as xanthine oxidase inhibitors: virtual hydrolysis, molecular docking, and in vitro activity evaluation)[J].食品科学与人类健康（英文）,2022(06):1591-1597
A类：
tripeptide,EEK,Glu802,Phe1009,Arg880
B类：
Identification,egg,derived,peptides,xanthine,oxidase,inhibitors,virtual,hydrolysis,docking,vitro,activity,evaluation,purpose,this,study,was,screen,XO,inhibitory,from,white,proteins,through,validation,results,demonstrated,that,ovalbumin,exhibited,IC50,value,showed,bound,center,via,carbon,hydrogen,interactions,salt,bridges,conventional,attractive,charge,residues,may,play,key,roles,catalytic,reaction,Especially,intermolecular,forces,inhibiting,be,type,bonds,including,attraction,novel,potential,candidates,controlling,hyperuricemia
AB值：
0.463332
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