典型文献
Advances in the pathogenesis of Rett syndrome using cell models
文献摘要：
Rett syndrome (RTT) is a progressive neurodevelopmental disorder that occurs mainly in girls with a range of typical symptoms of autism spectrum disorders. MeCP2 pro-tein loss- of- function in neural lineage cells is the main cause of RTT pathogenicity. As it is still hard to understand the mechanism of RTT on the basis of only clinical pa-tients or animal models, cell models cultured in vitro play indispensable roles . Here we reviewed the research progress in the pathogenesis of RTT at the cellular level, summarized the preclinical- research- related applications, and prospected potential future development.
文献关键词：
中图分类号：
作者姓名：
Sijia Lu;Yongchang Chen;Zhengbo Wang
作者机构：
State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine , Kunming University of Science and Technology , Kunming , China;Yunnan Key Laboratory of Primate Biomedical Research , Kunming , China
文献出处：
引用格式：
[1]Sijia Lu;Yongchang Chen;Zhengbo Wang-.Advances in the pathogenesis of Rett syndrome using cell models)[J].动物模型与实验医学（英文）,2022(06):532-541
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B类：
Advances,pathogenesis,Rett,syndrome,using,models,RTT,progressive,neurodevelopmental,that,occurs,mainly,girls,range,typical,symptoms,autism,spectrum,disorders,MeCP2,tein,loss,function,neural,lineage,cells,cause,pathogenicity,still,hard,understand,mechanism,basis,only,tients,animal,cultured,vitro,play,indispensable,roles,Here,reviewed,research,cellular,level,summarized,preclinical,related,applications,prospected,potential,future
AB值：
0.613452
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