典型文献
Respiratory plasticity following spinal cord injury: perspectives from mouse to man
文献摘要：
The study of respiratory plasticity in animal models spans decades. At the bench, researchers use an array of techniques aimed at harnessing the power of plasticity within the central nervous system to restore respiration following spinal cord injury. This field of research is highly clinically relevant. People living with cervical spinal cord injury at or above the level of the phrenic motoneuron pool at spinal levels C3–C5 typically have significant impairments in breathing which may require assisted ventilation. Those who are ventilator dependent are at an increased risk of ventilator-associated co-morbidities and have a drastically reduced life expectancy. Pre-clinical research examining respiratory plasticity in animal models has laid the groundwork for clinical trials. Despite how widely researched this injury is in animal models, relatively few treatments have broken through the preclinical barrier. The three goals of this present review are to define plasticity as it pertains to respiratory function post-spinal cord injury, discuss plasticity models of spinal cord injury used in research, and explore the shift from preclinical to clinical research. By investigating current targets of respiratory plasticity research, we hope to illuminate preclinical work that can influence future clinical investigations and the advancement of treatments for spinal cord injury.
文献关键词：
中图分类号：
作者姓名：
Katherine C.Locke;Margo L.Randelman;Daniel J.Hoh;Lyandysha V.Zholudeva;Michael A.Lane
作者机构：
Department of Neurobiology&Anatomy,Drexel University,Philadelphia,PA,USA;Marion Murray Spinal Cord Research Center,Philadelphia,PA,USA;Lillian S.Wells Department of Neurosurgery,University of Florida,Gainesville,FL,USA;Cardiovascular Disease,Gladstone Institutes,San Francisco,CA,USA
文献出处：
引用格式：
[1]Katherine C.Locke;Margo L.Randelman;Daniel J.Hoh;Lyandysha V.Zholudeva;Michael A.Lane-.Respiratory plasticity following spinal cord injury: perspectives from mouse to man)[J].中国神经再生研究（英文版）,2022(10):2141-2148
A类：
motoneuron
B类：
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AB值：
0.577364
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
