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典型文献
Hippocampal neurogenesis and pro-neurogenic therapies for Alzheimer's disease
文献摘要:
Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus- dependent cognition and emotion. However, AHN malfunc-tion has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elderly. Pro- neurogenic therapies in-cluding rescuing innate AHN, cell engraftment and glia- neuron reprogramming hold great potential for compensating the neuronal loss and rewiring the degenerated neu-ronal network in AD, but there are still great challenges to be overcome. This review covers recent advances in unraveling the involvement of AHN in AD and highlights the prospect of emerging pro- neurogenic remedies.
文献关键词:
作者姓名:
Jie Zheng
作者机构:
Department of Pharmacology,Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Key Laboratory of Basic Pharmacology of Guizhou Province,Zunyi Medical University,Zunyi,China
引用格式:
[1]Jie Zheng-.Hippocampal neurogenesis and pro-neurogenic therapies for Alzheimer's disease)[J].动物模型与实验医学(英文),2022(01):3-14
A类:
malfunc,ronal
B类:
Hippocampal,neurogenesis,neurogenic,therapies,Alzheimer,disease,Adult,hippocampal,AHN,facilitates,circuits,plasticity,regulates,hippocampus,dependent,cognition,emotion,However,has,been,widely,reported,both,human,animal,models,AD,most,common,form,dementia,elderly,Pro,cluding,rescuing,innate,cell,engraftment,glia,reprogramming,hold,great,potential,compensating,neuronal,loss,rewiring,degenerated,network,but,there,are,still,challenges,overcome,This,review,covers,recent,advances,unraveling,involvement,highlights,prospect,emerging,remedies
AB值:
0.666628
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