典型文献
MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography
文献摘要：
Homochiral metal-organic frameworks(MOFs)have attracted considerable attention in many fields of research,such as chiral catalysis and chiral chromatography.However,only few homochiral MOFs can be effectively used in capillary electrochromatography(CEC)and their performances are far from adequate.In this study,we successfully synthesized achiral nanocrystalline MIL-53.A facile post-synthetic modi-fication strategy was then implemented to functionalize the product,yielding a homochiral MOF:L-His-NH-MIL-53.This MOF was then employed as a chiral coating in open-tubular CEC mode(OT-CEC),and,as such,it exhibited high enantioselectivities for several racemic drugs.The homochiral MOF and the fabricated capillary coating were systematically characterized using transmission electron microscopy,scanning electron microscopy(with energy-dispersive X-ray spectrometry),Fourier-transform infrared spectroscopy,X-ray diffractometry,thermogravimetric analysis,circular dichroism spectroscopy,Bru-nauer-Emmett-Teller surface area measurements,and X-ray photoelectron spectroscopy.This study is expected to provide a new strategy for the design and establishment of MOF-based chiral OT-CEC systems.
文献关键词：
中图分类号：
作者姓名：
Xiaodong Sun;Bing Niu;Qi Zhang;Qin Chen
作者机构：
School of Medicine,Shanghai University,Shanghai,200444,China;School of Life Sciences,Shanghai University,Shanghai,200444,China;School of Pharmacy,Jiangsu University,Zhenjiang,Jiangsu,212013,China
文献出处：
引用格式：
[1]Xiaodong Sun;Bing Niu;Qi Zhang;Qin Chen-.MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography)[J].药物分析学报（英文）,2022(03):509-516
A类：
homochiral,Homochiral
B类：
MIL,metal,organic,stationary,phase,open,tubular,capillary,electrochromatography,frameworks,MOFs,have,attracted,considerable,attention,many,fields,research,such,catalysis,However,only,few,be,effectively,used,CEC,their,performances,far,from,adequate,In,this,study,successfully,synthesized,achiral,nanocrystalline,facile,post,synthetic,modi,fication,strategy,was,then,implemented,functionalize,product,yielding,His,NH,This,employed,coating,mode,OT,exhibited,high,enantioselectivities,several,racemic,drugs,fabricated,were,systematically,characterized,using,transmission,microscopy,scanning,energy,dispersive,ray,spectrometry,Fourier,transform,infrared,spectroscopy,diffractometry,thermogravimetric,analysis,circular,dichroism,Bru,nauer,Emmett,Teller,surface,area,measurements,photoelectron,expected,provide,new,design,establishment,systems
AB值：
0.603614
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