典型文献
In-vitro antioxidant and anti-inflammatory activities of ethanol stem-bark extract of Blighia sapida K.D.Koenig
文献摘要：
Blighia sapida(B.sapida)K.D.Koenig(Family Sapindaceae)is a branchless straight bole approximately 15 m in length.The study evaluated the antioxidant and anti-inflammatory activities of ethanol extract and fractions of B.sapida stem-bark using in vitro methods.Ethanol extract and its fractions were investigated for 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical scavenging activity,ferric reducing anti-oxidant power(FRAP),total antioxidant capacity(TAC),and quantitative phenolic and flavonoid contents.Anti-inflammatory activity was evaluated using albumin denaturation and membrane stabilization as-says.The extract and its fractions exhibited radical scavenging and anti-inflammatory properties.The ethyl acetate fraction possessed maximum phenolic and flavonoid contents(136.67±1.55 gallic acid equivalent mg/g and 75.76±4.03 quercetin equivalent mg/g,respectively).Antioxidant studies revealed that the ethyl acetate fraction displayed superior activity with an IC50=0.09±0.03 mg/mL DPPH,and values of 146.96±3.81 ascorbic acid equivalent(AAE)mg/g and 359.20±4.98 AAE mg/g for FRAP and TAC,respectively.Furthermore,the anti-inflammatory activity was revealed by inhibition of heat-induced albumin denaturation and red blood cell membrane stabilization at concentrations of 200-1000 μg/mL and 50-250 μg/mL,respectively.The ethanol extract and fractions exhibited antioxidant and anti-inflammatory activities,with ethyl acetate fraction showing superior activity,which could be attributed to secondary metabolites,mainly phenolic compounds.Overall,the antioxidant and anti-inflammatory activities of B.sapida can be exploited by ethnomedicinal users.
文献关键词：
中图分类号：
作者姓名：
Mukaila B.Adekola;Jacob O.Areola;Oladapo F.Fagbohun;Funke T.Asaolu;Gbenga E.Ogundepo;Adeniyi O.Fajobi;Olubunmi O.Babalola
作者机构：
Department of Environmental Management and Toxicology,Federal University of Agriculture,Abeokuta,110001,Nigeria;Department of Medical Biochemistry,Obafemi Awolowo University,Ile-Ife,230001,Nigeria;Department of Biomedical Engineering,First Technical University Ibadan,Oyo State,Ibadan,200001,Nigeria;Department of Biochemistry and Molecular Biology,Obafemi Awolowo University,Ile-Ife,230001,Nigeria
文献出处：
引用格式：
[1]Mukaila B.Adekola;Jacob O.Areola;Oladapo F.Fagbohun;Funke T.Asaolu;Gbenga E.Ogundepo;Adeniyi O.Fajobi;Olubunmi O.Babalola-.In-vitro antioxidant and anti-inflammatory activities of ethanol stem-bark extract of Blighia sapida K.D.Koenig)[J].药物分析学报（英文）,2022(02):350-354
A类：
Blighia,sapida,branchless,ethnomedicinal
B类：
In,vitro,antioxidant,inflammatory,activities,ethanol,stem,bark,extract,Koenig,Family,Sapindaceae,straight,bole,approximately,length,study,evaluated,fractions,using,methods,Ethanol,its,were,investigated,diphenyl,picrylhydrazyl,DPPH,radical,scavenging,activity,ferric,reducing,power,FRAP,total,capacity,TAC,quantitative,phenolic,flavonoid,contents,was,albumin,denaturation,membrane,stabilization,says,exhibited,properties,ethyl,acetate,possessed,maximum,gallic,acid,equivalent,quercetin,respectively,Antioxidant,studies,revealed,that,displayed,superior,IC50,values,ascorbic,AAE,Furthermore,by,inhibition,heat,induced,blood,cell,concentrations,showing,which,could,be,attributed,secondary,metabolites,mainly,compounds,Overall,can,exploited,users
AB值：
0.446943
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