典型文献
Successful liver transplantation from a donor with immune thrombocytopenia
文献摘要：
To the Editor: Immune thrombocytopenia(ITP)is an acquired autoimmune bleeding disease,which results from a combination of humoral and cell-mediated attacks on platelets and megakaryocytes[1-3].ITP patients are always presented as heterogeneous clinical bleeding manifestations.Fatal bleeding such as intracranial hemorrhage is the main cause of death,which turns the patients into potential organ donors.Several studies indicated that the donor lymphocytes secreting autoantibody may be transferred to recipients after trans-plantation[4,5].Transplantation-mediated alloimmune thrombocy-topenia(TMAT)was donor-derived thrombocytopenia after solid-organ transplantation[6].TMAT is a rare complication after trans-plantation,and the recipients of TMAT may present more severe bleeding events than the donors.A total of 6 recipients with TMAT after liver transplantation from ITP donors have been reported in-ternationally[6-11],among which 3 recipients died and 3 sur-vived.Thus,liver transplantation from ITP donors is relatively risky,and as a marginal donor organ,the use of ITP donor liver is contro-versial.There are no relevant guidelines for the safety assessment and treatment of ITP donor liver transplantation up to now.Here we reported a successful case with TMAT in liver transplant recip-ient from ITP donor in purpose of improving our understanding of TMAT.
文献关键词：
中图分类号：
作者姓名：
Wen-Tao Yang;Jing-Sheng Ma;Hong-Fei Zhu;Lin Zhong;Qi-Gen Li;Wen-Tao Yang
作者机构：
Department of Organ Transplantation,The Second Affiliated Hospital of Nanchang University,Nanchang 330000,China
文献出处：
引用格式：
[1]Wen-Tao Yang;Jing-Sheng Ma;Hong-Fei Zhu;Lin Zhong;Qi-Gen Li;Wen-Tao Yang -.Successful liver transplantation from a donor with immune thrombocytopenia)[J].国际肝胆胰疾病杂志(英文版),2022(03):299-302
A类：
Immune,megakaryocytes,thrombocy,topenia,TMAT,ternationally,vived,versial
B类：
Successful,liver,transplantation,from,thrombocytopenia,To,Editor,ITP,acquired,autoimmune,bleeding,disease,which,results,combination,humoral,cell,mediated,attacks,platelets,patients,always,presented,heterogeneous,clinical,manifestations,Fatal,such,intracranial,hemorrhage,main,cause,death,turns,into,potential,organ,donors,Several,studies,indicated,that,lymphocytes,secreting,autoantibody,may,transferred,recipients,after,Transplantation,alloimmune,was,derived,solid,rare,complication,more,severe,events,than,total,have,been,reported,among,died,sur,Thus,relatively,risky,marginal,contro,There,relevant,guidelines,safety,assessment,treatment,up,now,Here,we,successful,case,purpose,improving,our,understanding
AB值：
0.445675
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