典型文献
The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer
文献摘要：
Objective:T cell receptor-associated transmembrane adaptor 1(TRAT1)is one of the hub genes regulating T cell receptors(TCRs).Herein,the roles of TRAT1 in the prognosis and immune microenvironment of non-small cell lung cancer(NSCLC)were investigated.Methods:The expression and prognosis values of TRAT1 in NSCLC,and the relationship between TRAT1 expression levels and cancer immune cell infiltration was identified via the TIMER,UALCAN,TISIDB,and other databases.The mechanism of TRAT1 in NSCLC was analyzed using gene set enrichment analysis(GSEA).Results:The expression level of TRAT1 was decreased in NSCLC tissues.Low TRAT1 expression was associated with shorter overall survival of patients with NSCLC and was related to gender,smoking,and tumor grade.TRAT1 was involved in regulating immune response,TCR signaling pathway,PI3K/AKT,and other processes.TRAT1 expression levels were positively correlated with immune cell infiltration in NSCLC.Conclusion:Down-regulation of TRAT1 expression was associated with an unfavorable prognosis and immune infiltration of NSCLC.
文献关键词：
中图分类号：
作者姓名：
Qiang GUO;Si-hua WANG;Yan-mei JI;Song TONG;Dan LI;Xiang-chao DING;Chuang-yan WU
作者机构：
Department of Thoracic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Neurocritical Care Medicine,Taihe Hospital,Hubei University of Medicine,Shiyan 442000,China;Department of Oncology,Huanggang Central Hospital Affiliated to Yangtze University,Huanggang 438000,China;Department of Thoracic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China
文献出处：
引用格式：
[1]Qiang GUO;Si-hua WANG;Yan-mei JI;Song TONG;Dan LI;Xiang-chao DING;Chuang-yan WU-.The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer)[J].当代医学科学(英文),2022(06):1186-1200
A类：
TRAT1,TCRs
B类：
Roles,Mechanisms,Progression,Non,Small,Cell,Lung,Cancer,Objective,cell,associated,transmembrane,adaptor,one,hub,genes,regulating,receptors,Herein,roles,prognosis,immune,microenvironment,small,lung,cancer,NSCLC,were,investigated,Methods,expression,values,relationship,between,levels,infiltration,was,identified,via,TIMER,UALCAN,TISIDB,other,databases,mechanism,analyzed,using,set,enrichment,analysis,GSEA,Results,decreased,tissues,Low,shorter,overall,survival,patients,gender,smoking,tumor,grade,involved,response,signaling,pathway,PI3K,AKT,processes,positively,correlated,Conclusion,Down,regulation,unfavorable
AB值：
0.484104
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