典型文献
FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy
文献摘要：
Objective:Cancer/testis antigen FMR1NB is aberrantly expressed in various types of cancer,but not in normal tissues except for testis.This study aimed to investigate the expression and functional role of FMR1NB in glioma.Methods:The expression of FMR1NB mRNA and protein was determined using RT-PCR and immunohistochemistry,respectively,in glioma specimens from 83 patients at follow-up.The effects of siRNA-mediated FMR1NB silencing on malignant biological behaviors were evaluated in glioma cell lines Al 72 and U251.Results:FMR1NB mRNA and protein expression was detected in 58.8％(77/131)and 46.34％(57/123)of glioma tissues,respectively.FMR1NB protein was positively correlated with World Health Organization grade and found to be an independent prognostic marker for poor outcome.Knockdown of FMR1NB induced apoptosis and suppressed proliferation,adhesion,migration,and invasion by modulating the expression of cyclin A,CDK2,caspase-3,E-cadherin,and N-cadherin in A172 and U251 cells.Conclusion:Our findings suggest that FMR1NB contributes to the tumorigenesis of glioma cells and may represent a potential prognostic biomarker and an attractive therapeutic target in glioma.
文献关键词：
中图分类号：
作者姓名：
Shui-qing BI;Ya PENG;Zong-dang WEI;Sheng-zhong YAO;Bin LUO;Ying-ying GE;Xiao-xun XIE;Wei-xia NONG;Chang LIU;Shao-wen XIAO;Qing-mei ZHANG
作者机构：
Department of Neurosurgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Histology and Embryology,School of Pre-Clinical Medicine,Guangxi Medical University,Nanning 530021,China;Central Laboratory,School of Pre-Clinical Medicine,Guangxi Medical University,Nanning 530021,China
文献出处：
引用格式：
[1]Shui-qing BI;Ya PENG;Zong-dang WEI;Sheng-zhong YAO;Bin LUO;Ying-ying GE;Xiao-xun XIE;Wei-xia NONG;Chang LIU;Shao-wen XIAO;Qing-mei ZHANG-.FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy)[J].当代医学科学(英文),2022(04):803-816
A类：
FMR1NB,Tumorigenesis
B类：
Involved,Glioma,Is,Promising,Target,Prognosis,Therapy,Objective,Cancer,testis,antigen,aberrantly,expressed,various,types,cancer,not,normal,tissues,except,This,study,aimed,investigate,expression,functional,role,glioma,Methods,protein,was,determined,using,immunohistochemistry,respectively,specimens,from,patients,follow,effects,siRNA,mediated,silencing,malignant,biological,behaviors,were,evaluated,lines,U251,Results,detected,positively,correlated,World,Health,Organization,grade,found,independent,prognostic,poor,outcome,Knockdown,induced,apoptosis,suppressed,proliferation,adhesion,migration,invasion,by,modulating,cyclin,CDK2,caspase,cadherin,A172,cells,Conclusion,Our,findings,suggest,that,contributes,tumorigenesis,may,represent,potential,biomarker,attractive,therapeutic,target
AB值：
0.580312
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