典型文献
Molecular Detection of Ofloxacin and Kanamycin Resistance in Patients with MDR and Non-MDR TB from Suburban Districts in Hangzhou, China, 2019–2020
文献摘要：
The continuing emergence and spread of drug-resistant Mycobacterium tuberculosis complex (MTBC) poses a challenge to global tuberculosis (TB) control programs. Drug resistance in TB is mainly conferred by specific point mutations in the MTBC genome[1]. Multidrug-resistant TB (MDR-TB), which is caused by MTBC strains with resistance to both isoniazid and rifampicin (RIF), the most important first-line medicines, poses the main threat to TB control and elimination. Fluoroquinolones (FQs) and second-line injectable drugs (SLIDs) are core compounds in current MDR-TB treatment regimens[2]; however, data on the prevalence of resistance to FQs and SLIDs among MTBC strains has been lacking. The rapidly increasing number of DR-TB cases further underscores the need for more intensive surveillance of susceptibility to these important second-line drugs, to minimize further increases in the number of cases of preXDR-TB (MDR-TB with additional resistance to any FQ drug or at least one of the three SLIDs) and XDR-TB (MDR-TB with resistance to both FQs and SLIDs).
文献关键词：
中图分类号：
作者姓名：
JIA Qing Jun;ZENG Mei Chun;XIE Li;CHENG Qing Lin;HUANG Yin Yan;LI Qing Chun;WU Yi Fei;AI Li Yun;LU Min;FANG Zi Jian
作者机构：
Department of TB Control and Prevention, Hangzhou Center for Disease Control and Prevention, Hangzhou 310021,Zhejiang, China;Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University,Hangzhou 310003, Zhejiang, China
文献出处：
引用格式：
[1]JIA Qing Jun;ZENG Mei Chun;XIE Li;CHENG Qing Lin;HUANG Yin Yan;LI Qing Chun;WU Yi Fei;AI Li Yun;LU Min;FANG Zi Jian-.Molecular Detection of Ofloxacin and Kanamycin Resistance in Patients with MDR and Non-MDR TB from Suburban Districts in Hangzhou, China, 2019–2020)[J].生物医学与环境科学（英文版）,2022(05):468-471
A类：
Ofloxacin,Suburban,Districts,Fluoroquinolones,SLIDs,preXDR
B类：
Molecular,Detection,Kanamycin,Resistance,Patients,MDR,Non,from,Hangzhou,China,continuing,emergence,spread,resistant,Mycobacterium,tuberculosis,complex,MTBC,poses,challenge,global,control,programs,Drug,resistance,mainly,conferred,by,specific,point,mutations,genome,Multidrug,which,caused,strains,both,isoniazid,rifampicin,RIF,most,important,first,line,medicines,threat,elimination,FQs,second,injectable,drugs,are,compounds,current,treatment,regimens,however,data,prevalence,among,has,been,lacking,rapidly,increasing,number,cases,further,underscores,need,more,intensive,surveillance,susceptibility,these,minimize,increases,additional,any,least,three
AB值：
0.483553
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