典型文献
Subchronic Oral Toxicity Evaluation of Sodium Dehydroacetate: A 90-day Repeated Dose Study in Rats
文献摘要：
Objective The present study was undertaken to evaluate the subchronic oral toxicity of sodium dehydroacetate (DHA-Na) and to determine the point of departure (POD), which is a critical factor in the establishment of an acceptable dietary intake. Methods DHA-Na was administered once daily by gavage to Sprague–Dawley rats at dose levels of 0.0, 31.0, 62.0, and 124.0 mg/kg BW per day for 90 days, followed by a recovery period of 4 weeks in the control and 124.0 mg/kg BW per day groups. The outcome parameters were mortality, clinical observations, body weights, food consumption, hematology and clinical biochemistry, endocrine hormone levels, and ophthalmic, urinary, and histopathologic indicators. The benchmark dose (BMD) approach was applied to estimate the POD. Results Significant decreases were found in the 62.0 and 124.0 mg/kg BW groups in terms of the body weight and food utilization rate, whereas a significant increase was found in the thyroid stimulating hormone levels of the 124.0 mg/kg BW group. Importantly, the 95％ lower confidence limit on the BMD of 51.7 mg/kg BW was modeled for a reduction in body weight. Conclusion The repeated-dose study indicated the slight systemic toxicity of DHA-Na at certain levels (62.0 and 124.0 mg/kg BW) after a 90-day oral exposure.
文献关键词：
中图分类号：
作者姓名：
FANG Jin;LIU Hai Bo;ZHI Yuan;FENG Yong Quan;WANG Hui Ling;CUI Wen Ming;ZHANG Ji Yue;WANG Hua Li;YU Zhou;JIA Xu Dong
作者机构：
NHC Key Laboratory of Food Safety Risk Assessment,Chinese Academy of Medical Science Research Unit 2019RU014,China National Center for Food Safety Risk Assessment,Beijing 100021,China
文献出处：
引用格式：
[1]FANG Jin;LIU Hai Bo;ZHI Yuan;FENG Yong Quan;WANG Hui Ling;CUI Wen Ming;ZHANG Ji Yue;WANG Hua Li;YU Zhou;JIA Xu Dong-.Subchronic Oral Toxicity Evaluation of Sodium Dehydroacetate: A 90-day Repeated Dose Study in Rats)[J].生物医学与环境科学（英文版）,2022(04):296-311
A类：
Subchronic,Dehydroacetate,subchronic
B类：
Oral,Toxicity,Evaluation,Sodium,Repeated,Dose,Study,Rats,Objective,present,study,was,undertaken,evaluate,oral,toxicity,sodium,dehydroacetate,DHA,Na,determine,point,departure,POD,which,critical,establishment,acceptable,dietary,intake,Methods,administered,once,daily,by,gavage,Sprague,Dawley,rats,dose,levels,BW,days,followed,recovery,period,weeks,control,groups,outcome,parameters,were,mortality,clinical,observations,body,weights,food,consumption,hematology,biochemistry,endocrine,hormone,ophthalmic,urinary,histopathologic,indicators,benchmark,BMD,approach,applied,estimate,Results,Significant,decreases,found,terms,utilization,rate,whereas,significant,increase,thyroid,stimulating,Importantly,lower,confidence,limit,modeled,reduction,Conclusion,repeated,indicated,slight,systemic,certain,after,exposure
AB值：
0.593139
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
