典型文献
Is rosuvastatin protective against sepsis-associated encephalopathy? A secondary analysis of the SAILS trial
文献摘要：
BACKGROUND: Sepsis is a common cause of death in emergency departments and sepsis-associated encephalopathy (SAE) is a major complication. Rosuvastatin may play a neuroprotective role due to its protective effects on the vascular endothelium and its anti-inflammatory functions. Our study aimed to explore the potential protective function of rosuvastatin against SAE.METHODS: Sepsis patients without any neurological dysfunction on admission were prospectively enrolled in the "Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome" study (SAILS trial, ClinicalTrials.gov number: NCT00979121). Patients were divided into rosuvastatin and placebo groups. This is a secondary analysis of the SAILS dataset. Baseline characteristics, therapy outcomes, and adverse drug events were compared between groups. RESULTS: A total of 86 patients were eligible for our study. Of these patients, 51 were treated with rosuvastatin. There were significantly fewer cases of SAE in the rosuvastatin group than in the placebo group (32.1％ vs. 57.1％, P=0.028). However, creatine kinase levels were significantly higher in the rosuvastatin group than in the placebo group (233 [22–689] U/L vs. 79 [12–206] U/L, P=0.034). CONCLUSION: Rosuvastatin appears to have a protective role against SAE but may result in a higher incidence of adverse events.
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中图分类号：
作者姓名：
Shi-yuan Yu;Zeng-zheng Ge;Jun Xiang;Yan-xia Gao;Xin Lu;Joseph Harold Walline;Mu-bing Qin;Hua-dong Zhu;Yi Li
作者机构：
Emergency Department,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China;General Medicine Department of Jingnan Medical Center,General Hospital of PLA,Beijing 100039,China;Emergency Department,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Emergency Medicine,Penn State Health,Milton S.Hershey Medical Center,Hershey 17033,USA
文献出处：
引用格式：
[1]Shi-yuan Yu;Zeng-zheng Ge;Jun Xiang;Yan-xia Gao;Xin Lu;Joseph Harold Walline;Mu-bing Qin;Hua-dong Zhu;Yi Li-.Is rosuvastatin protective against sepsis-associated encephalopathy? A secondary analysis of the SAILS trial)[J].世界急诊医学杂志（英文）,2022(05):367-372
A类：
SAILS,Rosuvastatin,NCT00979121
B类：
Is,rosuvastatin,against,sepsis,associated,encephalopathy,secondary,analysis,trial,BACKGROUND,Sepsis,common,cause,death,emergency,departments,SAE,major,complication,may,play,neuroprotective,role,due,its,effects,vascular,endothelium,anti,inflammatory,functions,Our,study,aimed,explore,potential,METHODS,patients,without,any,neurological,dysfunction,admission,were,prospectively,enrolled,Associated,Acute,Respiratory,Distress,Syndrome,ClinicalTrials,gov,number,Patients,divided,into,placebo,groups,This,dataset,Baseline,characteristics,therapy,outcomes,adverse,drug,events,compared,between,RESULTS,total,eligible,our,Of,these,treated,There,significantly,fewer,cases,than,However,creatine,kinase,levels,higher,CONCLUSION,appears,have,but,result,incidence
AB值：
0.537737
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