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典型文献
Celebrating the discovery of DNA demethylaseFA
文献摘要:
Maintaining correct DNA methylation patterns entails the addition of methyl groups by DNA methyltransferases and the active removal of methylation from DNA. Removing a methyl group from 5-methylcytosine requires breaking a strong C–C bond, suggesting that demethylation might occur by an alternative mechanism that does not involve severing this bond. Indeed, the discovery of the 5-methylcytosine DNA glycosylase (also known as DNA demethylase) REPRESSOR OF SILENCING 1 (ROS1) by (Gong et al., 2002) revolutionized thinking in this field, as the study of ROS1 revealed a mechanism by which 5-methylcytosine is excised and replaced by the DNA repair machinery. This special issue celebrates the 20th anniversary of the discovery of ROS1 and the remarkable research that followed.
文献关键词:
作者姓名:
Zhizhong Gong;Jian-Kang Zhu
作者机构:
State Key Laboratory of Plant Physiology and Biochemistry,College of Biological Sciences,China Agricultural University,Beijing 100193,China;School of Life Sciences,Institute of Life Science and Green Development,Hebei University,Baoding 071002,China;School of Life Sciences,Institute of Advanced Biotechnology,Southern University of Science and Technology,Shenzhen 518055,China
引用格式:
[1]Zhizhong Gong;Jian-Kang Zhu-.Celebrating the discovery of DNA demethylaseFA)[J].植物学报(英文版),2022(12):2215-2216
A类:
demethylaseFA,severing,REPRESSOR,SILENCING
B类:
Celebrating,discovery,Maintaining,correct,patterns,entails,addition,groups,by,methyltransferases,active,removal,from,Removing,methylcytosine,requires,breaking,strong,bond,suggesting,that,demethylation,might,occur,alternative,mechanism,does,not,involve,this,Indeed,glycosylase,also,known,OF,ROS1,Gong,revolutionized,thinking,field,study,revealed,which,excised,replaced,repair,machinery,This,special,issue,celebrates,20th,anniversary,remarkable,research,followed
AB值:
0.573651
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