典型文献
The lncRNA39896–miR166b–HDZs module affects tomato resistance to Phytophthora infestans
文献摘要：
The yield and quality of tomatoes (Solanum lyco-persicum) is seriously affected by Phytophthora infestans. The long non-coding RNA (lncRNA) Sl-lncRNA39896 is induced after P. infestans in-fection and was previously predicted to act as an endogenous target mimic (eTM) for the mi-croRNA Sl-miR166b, which function in stress responses. Here, we further examined the role of Sl-lncRNA39896 and Sl-miR166b in tomato re-sistance to P. infestans. Sl-miR166b levels were higher in Sl-lncRNA39896-knockout mutants than in wild-type plants, and the mutants displayed enhanced resistance to P. infestans. A six-point mutation in the region of Sl-lncRNA39896 that binds to Sl-miR166b disabled the interaction, suggesting that Sl-lncRNA39896 acts as an eTM for Sl-miR166b. Overexpressing Sl-miR166b yielded a similar phenotype to that produced by Sl-lncRNA39896-knockout, whereas silencing of Sl-miR166b impaired resistance. We verified that Sl-miR166b cleaved transcripts of its target class Ⅲ homeodomain-leucine zipper genes SlHDZ34 and SlHDZ45. Silencing of SlHDZ34/45 decreased pathogen accumulation in plants infected with P. infestans. Additionally, jasmonic acid and ethylene contents were elevated following infection in the plants with enhanced resistance. Sl-lncRNA39896 is the first known lncRNA to negatively regulate resistance to P. infestans in tomato. We propose a novel mechanism in which the lncRNA39896–miR166b–HDZ module modulates resistance to P. infestans.
文献关键词：
中图分类号：
作者姓名：
Yuhui Hong;Yuanyuan Zhang;Jun Cui;Jun Meng;Yinhua Chen;Chengwei Zhang;Jinxiao Yang;Yushi Luan
作者机构：
School of Bioengineering,Dalian University of Technology,Dalian 116024,China;State Key Laboratory of Rice Biology,China National Rice Research Institute,Hangzhou 311400,China;College of Life Science,Hunan Normal University,Changsha 410081,China;School of Computer Science and Technology,Dalian University of Technology,Dalian 116024,China;Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource,College of Tropical Crops,Hainan University,Haikou 570228,China;Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding,Beijing Academy of Agriculture&Forestry Sciences,Beijing 100000,China
文献出处：
引用格式：
[1]Yuhui Hong;Yuanyuan Zhang;Jun Cui;Jun Meng;Yinhua Chen;Chengwei Zhang;Jinxiao Yang;Yushi Luan-.The lncRNA39896–miR166b–HDZs module affects tomato resistance to Phytophthora infestans)[J].植物学报（英文版）,2022(10):1979-1993
A类：
lncRNA39896,miR166b,HDZs,lyco,eTM,SlHDZ34,SlHDZ45,HDZ
B类：
module,affects,resistance,Phytophthora,infestans,quality,tomatoes,Solanum,persicum,seriously,affected,by,long,coding,induced,after,was,previously,predicted,endogenous,target,mimic,croRNA,which,function,stress,responses,Here,further,examined,role,levels,were,higher,knockout,mutants,than,wild,plants,displayed,enhanced,six,point,mutation,region,that,binds,disabled,interaction,suggesting,acts,Overexpressing,yielded,similar,phenotype,produced,whereas,silencing,impaired,We,verified,cleaved,transcripts,its,class,homeodomain,leucine,zipper,genes,Silencing,decreased,pathogen,accumulation,infected,Additionally,jasmonic,acid,ethylene,contents,elevated,following,infection,first,known,negatively,regulate,propose,novel,mechanism,modulates
AB值：
0.378146
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