典型文献
Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage,inhibiting ATM/SOG1-mediated DNA damage response,and antagonizing global DNA hypermethylation
文献摘要：
Arabidopsis methylation elevated mutant 1 (mem1)mutants have elevated levels of global DNA meth-ylation.In this study,such mutant alleles showed increased sensitivity to methyl methanesulfonate(MMS).In mem1 mutants,an assortment of genes engaged in DNA damage response (DDR),espe-cially DNA-repair-associated genes,were largely upregulated without MMS treatment,suggestive of activation of the DDR pathway in them.Following MMS treatment,expression levels of multiple DNA-repair-associated genes in mem1 mutants were generally lower than in Col-0 plants,which accounted for the MMS-sensitive phenotype of the mem1 mutants.A group of DNA methylation pathway genes were upregulated in mem1 mutants under non-MMS-treated conditions,causing ele-vated global DNA methylation,especially in RNA-directed DNA methylation (RdDM)-targeted regions.Moreover,MEM1 seemed to help ATAXlA-TELANGIECTASIA MUTATED (ATM) and/or SUP-PRESSOR OF GAMMA RESPONSE 1 (SOG1) to fully activate/suppress transcription of a subset of genes regulated simultaneously by MEM1 and ATM and/or SOG1,because expression of such genes decreased/increased consistently in mem 1 and atm and/or sog1 mutants,but the decreases/increases in the mem1 mutants were not as dramatic as in the atm and/or sog1 mutants.Thus,our studies reveals roles of MEM1 in safeguarding genome,and inter-relationships among DNA damage,activation of DDR,DNA methylation/demethylation,and DNA repair.
文献关键词：
中图分类号：
作者姓名：
Qianqian Wang;Yumei La;Huihui Xia;Shaoxia Zhou;Zhaoyu Zhai;Honggui La
作者机构：
College of Life Sciences,Nanjing Agricultural University,Nanjing 210095,China;College of Plant Protection,Nanjing Agricultural University,Nanjing 210095,China;College of Artificial Intelligence,Nanjing Agricultural University,Nanjing 210095,China
文献出处：
引用格式：
[1]Qianqian Wang;Yumei La;Huihui Xia;Shaoxia Zhou;Zhaoyu Zhai;Honggui La-.Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage,inhibiting ATM/SOG1-mediated DNA damage response,and antagonizing global DNA hypermethylation)[J].植物学报（英文版）,2022(01):87-104
A类：
MEM1,SOG1,mem1,RdDM,ATAXlA,TELANGIECTASIA,MUTATED,PRESSOR,sog1
B类：
Roles,safeguarding,Arabidopsis,genome,against,damage,inhibiting,ATM,mediated,response,antagonizing,global,hypermethylation,elevated,mutants,have,levels,In,this,study,such,alleles,showed,increased,sensitivity,methanesulfonate,MMS,assortment,genes,engaged,DDR,repair,associated,were,largely,upregulated,without,treatment,suggestive,activation,pathway,them,Following,expression,multiple,generally,lower,Col,plants,which,accounted,sensitive,phenotype,group,under,treated,conditions,causing,especially,directed,targeted,regions,Moreover,seemed,help,SUP,OF,GAMMA,RESPONSE,fully,activate,suppress,transcription,subset,simultaneously,by,because,decreased,consistently,but,decreases,increases,dramatic,Thus,our,studies,reveals,roles,inter,relationships,among,demethylation
AB值：
0.403364
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