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典型文献
The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders
文献摘要:
Brain injury-induced neurological deficits typically develop on the contralateral side of the body and include abnormal posture, motor weakness, and spasticity. It is believed that the interruption of descending neural pathways that convey supraspinal commands to the motoneurons in the spinal cord is the main cause of these deficits. This long-standing paradigm was challenged by our recent findings: a unilateral injury of the hindlimb sensorimotor cortex of rats with prior complete transection of the spinal cord produced hindlimb postural asymmetry (HL-PA), asymmetric hindlimb withdrawal reflexes, and asymmetry in gene expression patterns in the lumbar spinal cord (Figure 1; Lukoyanov et al., 2021). Strikingly, the contralateral hindlimb was flexed as usually seen in rats with intact spinal cord after brain injury.
文献关键词:
作者姓名:
Georgy Bakalkin;Nikolay Lukoyanov;Igor Lavrov;Mengliang Zhang
作者机构:
Department of Pharmaceutical Biosciences,Uppsala University,Uppsala,Sweden;Departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto,Instituto de Investiga??o e Inova??o em Saúde,Instituto de Biologia Molecular e Celular,Porto,Portugal;Department of Neurology,Mayo Clinic,Rochester,MN,USA;Department of Molecular Medicine,University of Southern Denmark,Odense,Denmark
引用格式:
[1]Georgy Bakalkin;Nikolay Lukoyanov;Igor Lavrov;Mengliang Zhang-.The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders)[J].中国神经再生研究(英文版),2022(11):2431-2433
A类:
supraspinal,motoneurons,reflexes,Lukoyanov,flexed
B类:
left,right,side,specific,endocrine,signaling,implications,neurological,deficits,stroke,neurodevelopmental,disorders,Brain,injury,induced,typically,contralateral,body,include,abnormal,posture,weakness,spasticity,It,believed,that,interruption,descending,neural,pathways,convey,commands,cord,main,cause,these,This,long,standing,paradigm,was,challenged,by,our,recent,findings,unilateral,hindlimb,sensorimotor,cortex,rats,prior,complete,transection,produced,postural,asymmetry,HL,PA,asymmetric,withdrawal,gene,expression,patterns,lumbar,Figure,Strikingly,usually,seen,intact,after,brain
AB值:
0.589622
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