典型文献
Temporal alterations in pericytes at the acute phase of ischemia/reperfusion in the mouse brain
文献摘要：
Pericytes, as the mural cells surrounding the microvasculature, play a critical role in the regulation of microcirculation; however, how these cells respond to ischemic stroke remains unclear. To determine the temporal alterations in pericytes after ischemia/reperfusion, we used the 1-hour middle cerebral artery occlusion model, which was examined at 2, 12, and 24 hours after reperfusion. Our results showed that in the reperfused regions, the cerebral blood flow decreased and the infarct volume increased with time. Furthermore, the pericytes in the infarct regions contracted and acted on the vascular endothelial cells within 24 hours after reperfusion. These effects may result in incomplete microcirculation reperfusion and a gradual worsening trend with time in the acute phase. These findings provide strong evidence for explaining the "no-reflow" phenomenon that occurs after recanalization in clinical practice.
文献关键词：
中图分类号：
作者姓名：
Shuang Zhang;Xue-Jing Liao;Jia Wang;Yi Shen;Han-Fen Shi;Yan Zou;Chong-Yang Ma;Xue-Qian Wang;Qing-Guo Wang;Xu Wang;Ming-Yang Xu;Fa-Feng Cheng;Wan-Zhu Bai
作者机构：
Beijing Key Laboratory,School of Basic Medical Sciences,Beijing University of Chinese Medicine,Beijing,China;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing,China;Shineway Pharmaceutical Group Ltd.,Shijiazhuang,Hebei Province,China;School of Traditional Chinese Medicine,Capital Medical University,Beijing,China
文献出处：
引用格式：
[1]Shuang Zhang;Xue-Jing Liao;Jia Wang;Yi Shen;Han-Fen Shi;Yan Zou;Chong-Yang Ma;Xue-Qian Wang;Qing-Guo Wang;Xu Wang;Ming-Yang Xu;Fa-Feng Cheng;Wan-Zhu Bai-.Temporal alterations in pericytes at the acute phase of ischemia/reperfusion in the mouse brain)[J].中国神经再生研究（英文版）,2022(10):2247-2252
A类：
reperfused
B类：
Temporal,alterations,pericytes,acute,phase,ischemia,reperfusion,mouse,brain,Pericytes,mural,cells,surrounding,microvasculature,play,critical,role,regulation,microcirculation,however,these,respond,ischemic,stroke,remains,unclear,To,determine,temporal,after,middle,cerebral,artery,occlusion,model,which,was,examined,hours,Our,results,showed,that,regions,blood,decreased,infarct,volume,increased,Furthermore,contracted,vascular,endothelial,within,These,effects,may,incomplete,gradual,worsening,trend,findings,provide,strong,evidence,explaining,reflow,phenomenon,occurs,recanalization,clinical,practice
AB值：
0.586106
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