典型文献
Repurposed anti-cancer epidermal growth factor receptor inhibitors:mechanisms of neuroprotective effects in Alzheimer's disease
文献摘要：
Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer's disease.Recent studies have shown the beneficial effects of epidermal growth factor receptor inhibitors on the enhancement of behavioral and pathological sequelae in Alzheimer's disease.Despite the promising effects of epidermal growth factor receptor inhibitors in Alzheimer's disease,there is no irrefutable neuroprotective evidence in well-established animal models using epidermal growth factor receptor inhibitors due to many un-explored downstream signaling pathways.This caused controversy about the potential involvement of epidermal growth factor receptor inhibitors in any prospective clinical trial.In this review,the mystery beyond the under-investigation of epidermal growth factor receptor in Alzheimer's disease will be discussed.Furthermore,their molecular mechanisms in neurodegeneration will be explained.Also,we will shed light on SARS-COVlD-19 induced neurological manifestations mediated by epidermal growth factor modulation.Finally,we will discuss future perspectives and under-examined epidermal growth factor receptor downstream signaling pathways that warrant more exploration.We conclude that epidermal growth factor receptor inhibitors are novel effective therapeutic approaches that require further research in attempts to be repositioned in the delay of Alzheimer's disease progression.
文献关键词：
中图分类号：
作者姓名：
Heba M.Mansour;Hala M.Fawzy;Aiman S.EI-Khatib;Mahmoud M.Khattab
作者机构：
Department of Pharmacology,Egyptian Drug Authority,EDA,formerly NODCAR,Giza,Egypt;Department of Pharmacology and Toxicology,Faculty of Pharmacy,Cairo University,Cairo,Egypt
文献出处：
引用格式：
[1]Heba M.Mansour;Hala M.Fawzy;Aiman S.EI-Khatib;Mahmoud M.Khattab-.Repurposed anti-cancer epidermal growth factor receptor inhibitors:mechanisms of neuroprotective effects in Alzheimer's disease)[J].中国神经再生研究（英文版）,2022(09):1913-1918
A类：
Repurposed,irrefutable
B类：
anti,cancer,epidermal,growth,receptor,inhibitors,mechanisms,neuroprotective,effects,Alzheimer,disease,Numerous,molecular,are,being,examined,discover,modifying,drugs,slow,underlying,neurodegeneration,Recent,studies,have,shown,beneficial,enhancement,behavioral,pathological,sequelae,Despite,promising,there,evidence,well,established,animal,models,using,due,many,explored,downstream,signaling,pathways,This,caused,controversy,about,potential,involvement,prospective,clinical,trial,In,this,review,mystery,beyond,investigation,will,discussed,Furthermore,their,explained,Also,light,SARS,COVlD,induced,neurological,manifestations,mediated,by,modulation,Finally,future,perspectives,that,warrant,exploration,We,conclude,novel,effective,therapeutic,approaches,require,further,research,attempts,repositioned,delay,progression
AB值：
0.518896
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