典型文献
Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy
文献摘要：
Studies in animals indicate that sevoflurane exposure in the second trimester of pregnancy has harmful effects on the learning and memory of offspring.Whether an enriched environment can reverse the damage of sevoflurane exposure in the second trimester of pregnancy on the learning and memory of rat offspring remains unclear.In this study,rats at 14 days of pregnancy were exposed to 3.5％sevoflurane for 2 hours and their offspring were treated with an enriched environment for 20 successive days.We found that the enriched environment for offspring increased nestin and Ki67 levels in hippocampal tissue,increased hippocampal neurogenesis,inhibited glycogen synthase kinase 3β activity,and increased the expression of cell proliferation-related β-catenin and apoptosis-related Bcl-2,indicating that an enriched environment reduces sevoflurane-induced damage by increasing the proliferation of stem cells in the hippocampus.These findings suggest that an enriched environment can reverse the effects of sevoflurane inhaled by rats during the second trimester of pregnancy on learning and memory of offspring.This study was approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University(approval No.2018PS07K)on January 2,2018.
文献关键词：
中图分类号：
作者姓名：
Shao-Wei Yin;Yi-Lin Meng;Chuang Li;Yuan Wang
作者机构：
Department of Obstetrics,Shengjing Hospital of China Medical University,Shenyang,Liaoning Province,China;Department of Anesthesiology,Shengjing Hospital of China Medical University,Shenyang,Liaoning Province,China
文献出处：
引用格式：
[1]Shao-Wei Yin;Yi-Lin Meng;Chuang Li;Yuan Wang-.Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy)[J].中国神经再生研究（英文版）,2022(06):1293-1298
A类：
Shengjing,2018PS07K
B类：
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AB值：
0.475413
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