典型文献
Leukoaraiosis is associated with clinical symptom severity, poor neurological function prognosis and stroke recurrence in mild intracerebral hemorrhage: a prospective multi-center cohort study
文献摘要：
Leukoaraiosis (LA) results from ischemic injury in small cerebral vessels, which may be attributable to decreased vascular density, reducedcerebrovascular angiogenesis, decreased cerebral blood flow, or microcirculatory dysfunction in the brain. In this study, we enrolled 357 patients with mild intracerebral hemorrhage (ICH) from five hospitals in China and analyzed the relationships between LA and clinical symptom severity at admission, neurological function prognosis at 3 months, and 1-year stroke recurrence. Patients were divided into groups based on Fazekas scale scores: no LA (n = 83), mild LA (n = 64), moderate LA (n = 98) and severe LA (n = 112). More severe LA, larger hematoma volume, and higher blood glucose level at admission were associated with more severe neurological deficit. More severe LA, older age and larger hematoma volume were associated with worse neurological function prognosis at 3 months. In addition, moderate-to-severe LA, admission glucose and symptom-free cerebral infarction were associated with 1-year stroke recurrence. These findings suggest that LA severity may be a potential marker of individual ICH vulnerability, which can be characterized by poor tolerance to intracerebral attack or poor recovery ability after ICH. Evaluating LA severity in patients with mild ICH may help neurologists to optimize treatment protocols. This study was approved by the Ethics Committee of Ruijin Hospital Affiliated to Shanghai Jiao Tong University (approval No. 12) on March 10, 2011.
文献关键词：
中图分类号：
作者姓名：
Tian-Qi Xu
作者机构：
Department of Neurology, Ruijin Hospital/Luwan Branch, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;The Third Affiliated People'sHospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China;Department of Neurology, Minhang Hospital, Fudan University, Shanghai, China;Department of Neurology, Ruijin North Hospital, Shanghai, China;Department of Neurology, Zhongshan Hospital Qingpu Branch, Fudan University, Shanghai, China;Department of Neurology, The First Hospital of Jiaxing, Jiaxing, Zhejiang Province, China;Department of Rehabilitation, Shanghai Ruijin Rehabilitation Hospital, Shanghai, China
文献出处：
引用格式：
[1]Tian-Qi Xu-.Leukoaraiosis is associated with clinical symptom severity, poor neurological function prognosis and stroke recurrence in mild intracerebral hemorrhage: a prospective multi-center cohort study)[J].中国神经再生研究（英文版）,2022(04):819-823
A类：
Leukoaraiosis,reducedcerebrovascular,neurologists,Ruijin
B类：
associated,clinical,symptom,severity,poor,neurological,prognosis,stroke,recurrence,mild,intracerebral,hemorrhage,prospective,multi,center,cohort,study,LA,results,from,ischemic,injury,small,vessels,which,may,attributable,decreased,density,angiogenesis,blood,flow,microcirculatory,dysfunction,brain,In,this,enrolled,patients,ICH,five,hospitals,China,analyzed,relationships,between,admission,months,year,Patients,were,divided,into,groups,Fazekas,scale,scores,moderate,severe,More,larger,hematoma,volume,higher,glucose,level,more,deficit,older,worse,addition,free,infarction,These,findings,suggest,that,potential,marker,individual,vulnerability,can,characterized,by,tolerance,attack,recovery,after,Evaluating,help,optimize,treatment,protocols,This,was,approved,Ethics,Committee,Hospital,Affiliated,Shanghai,Jiao,Tong,University,approval,No,March
AB值：
0.505546
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
