典型文献
Fibrosis as a common trait in amyotrophic lateral sclerosis tissues
文献摘要：
Amyotrophic lateral sclerosis (ALS) is a highly aggressive adult-onset neurodegenerative disease caused by the progressive loss of upper and lower motor neurons. Clinically, it causes irreversible muscle atrophy and spasticity, leading to death due to respiratory failure, usually within 2–5 years after the first symptom onset. Approximately 85％ of ALS cases are classified as sporadic, while the remaining 15％ are of familial origin, but the overall clinical and molecular features of the disease are almost undistinguishable in the two forms. The majority of familial ALS cases are caused by pathogenic variants of C9orf72, SOD1, TARDBP, FUS, ANG and OPTN genes that are inherited by a Mendelian pattern and display high penetrance (Kiernan et al., 2020).
文献关键词：
中图分类号：
作者姓名：
Savina Apolloni
作者机构：
Department of Biology,University of Rome Tor Vergata,Rome,Italy
文献出处：
引用格式：
[1]Savina Apolloni-.Fibrosis as a common trait in amyotrophic lateral sclerosis tissues)[J].中国神经再生研究（英文版）,2022(01):97-98
A类：
undistinguishable,OPTN,penetrance,Kiernan
B类：
Fibrosis,common,trait,amyotrophic,lateral,sclerosis,tissues,Amyotrophic,ALS,highly,aggressive,adult,onset,neurodegenerative,disease,caused,by,progressive,loss,upper,lower,motor,neurons,Clinically,causes,irreversible,muscle,atrophy,spasticity,leading,death,due,respiratory,failure,usually,within,years,after,first,symptom,Approximately,cases,are,classified,sporadic,while,remaining,familial,origin,but,overall,clinical,molecular,features,almost,two,forms,majority,pathogenic,variants,C9orf72,SOD1,TARDBP,FUS,ANG,genes,that,inherited,Mendelian,pattern,display
AB值：
0.680984
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
