典型文献
Concise syntheses of 13-methylprotoberberine and 13-methyltetrahydroprotoberberine alkaloids
文献摘要：
The concise syntheses of eight 13-methylprotoberberine(13-MePB)and eight enantioenriched 13-methyltetrahydroprotoberberine(13-MeTHPB)alkaloids have been achieved in a tactically modular fash-ion.This synthetic work features a one-pot metal-free Pictet-Spengler/Friedel-Crafts hydroxyalkyla-tion/dehydration/oxidation sequence and a following highly enantioselective Ir-catalyzed hydrogenation.Given such brevity and modularity,our developed synthetic route would be greatly beneficial to the effi-cient syntheses of existing natural products and new fully synthetic variants of 13-MePB and 13-MeTHPB family.
文献关键词：
中图分类号：
作者姓名：
Wenchang Chen;Xiaofen Yi;Hongmin Qu;Yu Chen;Pei Tang;Fener Chen
作者机构：
Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China;Engineering Center of Catalysis and Synthesis for Chiral Molecules,Department of Chemistry,Fudan University,Shanghai 200433,China;hanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs,Shanghai 200433,China
文献出处：
引用格式：
[1]Wenchang Chen;Xiaofen Yi;Hongmin Qu;Yu Chen;Pei Tang;Fener Chen-.Concise syntheses of 13-methylprotoberberine and 13-methyltetrahydroprotoberberine alkaloids)[J].中国化学快报（英文版）,2022(12):5080-5083
A类：
methylprotoberberine,methyltetrahydroprotoberberine,MePB,MeTHPB,tactically,hydroxyalkyla
B类：
Concise,syntheses,alkaloids,concise,eight,enantioenriched,have,been,achieved,fash,This,synthetic,work,features,one,pot,metal,free,Pictet,Spengler,Friedel,Crafts,dehydration,oxidation,sequence,following,highly,enantioselective,Ir,catalyzed,hydrogenation,Given,such,brevity,modularity,our,developed,route,would,greatly,beneficial,effi,cient,existing,natural,products,new,fully,variants,family
AB值：
0.605382
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