典型文献
Insight into the in vivo fate of intravenous herpetrione amorphous nanosuspensions by aggregation-caused quenching probes
文献摘要：
Intravenous nanosuspensions are attracted growing attention as a viable strategy for development of in-travenous formulations of poorly water-soluble drugs.However,only few information about the biological fate of intravenous nanosuspensions is currently known,especially amorphous nanosuspensions are not reported yet.In this study,the in vivo fate of herpetrione(HPE)amorphous nanosuspensions follow-ing intravenous administration was explored by using an aggregation-caused quenching(ACQ)probe and HPLC methods.The ACQ probe is physically embedded into HPE nanoparticles via anti-solvent method to form HPE hybrid nanosuspensions(HPE-HNSs)for bioimaging.HPE-HNSs emit strong and stable fluo-rescence,but fluorescence quenches immediately upon the dissolution of HPE-HNSs,confirming the self-discrimination of HPE-HNSs.Following intravenous administration of HPE-HNSs,integral HPE-HNSs and HPE show similar degradation and biodistribution,with rapid clearance from blood circulation and obvi-ous accumulation in liver and lung.Due to the slower dissolution and enhanced recognition by reticulo-endothelial system,450 nm HPE-HNSs accumulate more in liver,lung and spleen than that of 200 nm HPE-HNSs.These results demonstrate that integral HPE-HNSs determine the in vivo performance of HPE-HNSs.This study provides insight into the in vivo fate of intravenous amorphous nanosuspensions.
文献关键词：
中图分类号：
作者姓名：
Lingyu Hang;Chengying Shen;Baode Shen;Hailong Yuan
作者机构：
Department of Pharmacy,Air Force Medical Center,PLA,Beijing 100142,China;College of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Department of Pharmacy,Jiangxi Provincial People's Hospital,Nanchang 330006,China
文献出处：
引用格式：
[1]Lingyu Hang;Chengying Shen;Baode Shen;Hailong Yuan-.Insight into the in vivo fate of intravenous herpetrione amorphous nanosuspensions by aggregation-caused quenching probes)[J].中国化学快报（英文版）,2022(11):4948-4951
A类：
herpetrione,travenous,HNSs,reticulo
B类：
Insight,into,vivo,fate,intravenous,amorphous,nanosuspensions,by,aggregation,caused,quenching,probes,Intravenous,are,attracted,growing,attention,viable,strategy,development,formulations,poorly,water,soluble,drugs,However,only,few,information,about,biological,currently,known,especially,not,reported,yet,this,study,HPE,follow,administration,was,explored,using,ACQ,HPLC,methods,physically,embedded,nanoparticles,anti,solvent,hybrid,bioimaging,emit,strong,stable,fluorescence,quenches,immediately,upon,dissolution,confirming,self,discrimination,Following,integral,show,similar,degradation,biodistribution,rapid,clearance,from,blood,circulation,obvi,accumulation,liver,lung,Due,slower,enhanced,recognition,endothelial,system,accumulate,more,spleen,than,that,These,results,demonstrate,determine,performance,This,provides,insight
AB值：
0.450641
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