典型文献
Nickel-catalyzed reductive cross-coupling of polyfluoroarenes with alkyl electrophiles by site-selective C-F bond activation
文献摘要：
A nickel-catalyzed reductive cross-coupling reactions between polyfluoroarenes and alkyl electrophiles is reported to access substituted fluoroarenes through chelation-assisted C-F activation.Diverse primary and secondary alkyl(pseudo)halides can be employed to couple with polyfluoroarenes,showing excellent regioselectivity.Furthermore,the nickel-catalyzed asymmetric cross-coupling of polyfluoroarenes with racemic alkyl halides is preliminarily explored.In addition,the practicability of the title transforma-tion is also demonstrated by total synthesis of losmapimod and an analog as key steps.The developed method exhibits many advantages,including economic catalytic systems,commercially available alkyl electrophiles,and lack of sensitive organometallic reagents.
文献关键词：
中图分类号：
作者姓名：
Longlong Xi;Liting Du;Zhuangzhi Shi
作者机构：
State Key Laboratory of Coordination Chemistry,Chemistry and Biomedicine Innovation Center(ChemBIC),School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210093,China;Advanced Analysis and Testing Center,Nanjing Forestry University,Nanjing 210037,China
文献出处：
引用格式：
[1]Longlong Xi;Liting Du;Zhuangzhi Shi-.Nickel-catalyzed reductive cross-coupling of polyfluoroarenes with alkyl electrophiles by site-selective C-F bond activation)[J].中国化学快报（英文版）,2022(09):4287-4292
A类：
polyfluoroarenes,fluoroarenes,losmapimod
B类：
Nickel,catalyzed,reductive,cross,coupling,alkyl,electrophiles,by,site,selective,bond,activation,nickel,reactions,between,reported,access,substituted,through,chelation,assisted,Diverse,primary,secondary,pseudo,halides,can,employed,couple,showing,excellent,regioselectivity,Furthermore,asymmetric,racemic,preliminarily,explored,In,addition,practicability,title,transforma,also,demonstrated,total,synthesis,analog,key,steps,developed,method,exhibits,many,advantages,including,economic,catalytic,systems,commercially,available,lack,sensitive,organometallic,reagents
AB值：
0.59761
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