Regiodivergent catalysis provides an efficient strategic approach for the construction of architecturally different molecules from the same starting materials.In this field,the intermolecular regiodivergent 1,2-difunctionalization of alkenes with two elec-trophiles is still a challenging task.A ligand-controlled,nickel-catalyzed regiodivergent dicarbofunctionalization of alkenes using both aryl/vinyl halides and acetals as electrophiles under mild reductive reaction conditions has been accomplished.This study provides a general approach to accessing both β-methoxyl esters and y-methoxyl esters from readily available acrylates,aryl halides and acetals.Experimental mechanistic evidence supports that the difference in regioselective outcomes is attributed to the ligand tuning the reactivity of the nickel catalyst,which results in different catalytic cycles operating for these two reaction conditions.

Institute for Advanced Studies,Wuhan University,Wuhan 430072,China;Institute of Biomedical Materials Industry Technology,Hubei Engineering University,Wuhan 430074,China

[1]Md.Belal;Zheqi Li;Lei Zhu;Guoyin Yin-.Catalyst-controlled regiodivergent 1,2-difu nctionalization of alkenes with two carbon-based electrophiles)[J].中国科学:化学（英文版）,2022(03):514-520

regiodivergent,difu,nctionalization,Regiodivergent,architecturally,difunctionalization,trophiles,dicarbofunctionalization,acetals

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