Owing to frequent environmental monitoring of tetrabromobisphenol-A(TBBPA)analogs and their poten-tial ecotoxicological effects on organisms,analysis of trace levels of TBBPA analogs with more non-polar and less water-soluble characteristics is of great significance for studying their environmental behaviors and toxic effects.Herein,a fast and sensitive technique is developed for directly detecting aqueous TBBPA analogs,including TBBPA mono(allyl ether)(TBBPA-MAE),TBBPA mono(2,3-dibromopropyl ether)(TBBPA-MDBPE),TBBPA mono(2-hydroxyethyl ether)(TBBPA-MHEE)and TBBPA mono(glycidyl ether)(TBBPA-MGE),by combining solid phase microextraction(SPME)based on porous covalent organic frameworks(Porous-COFs)with constant flow desorption ionization-mass spectrometry(CFDI-MS).As chromato-graphic separation is replaced by constant flow desorption,each sample can be analyzed within 7 min.The hierarchical porous structures(microporous,mesoporous and macroporous)of COFs lead to the en-hanced mass transfer and the easier accessibility of active sites to TBBPA analogs,so that the extraction efficiency is 2.3-3.6 times higher than pure microporous COFs,and far superior to commercial coatings.The detection limit and quantification limit of this method are 0.1-1 and 0.4-3.2 ng/L,respectively.Ultra-trace levels of TBBPA analogs from 5.0 ng/L to 66 ng/L have been successfully detected in river and sea water samples,showing great potential for subsequent studies of their environmental behaviors and tox-icological effects

Research Center for Analytical Sciences,Department of Chemistry,College of Sciences,Northeastern University,Shenyang 110819,China;CAS Key Laboratory of Biobased Materials,Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,Qingdao 266101,China;College of Environmental Science and Engineering,Qingdao University,Qingdao 266071,China;State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China;Innovation Academy for Green Manufacture,Chinese Academy of Sciences,Beijing 100190,China

[1]Wei Gao;Min Li;Yun Fa;Zongshan Zhao;Yaqi Cai;Xiangfeng Liang;Yongliang Yu;Guibin Jiang-.Porous covalent organic frameworks-improved solid phase microextraction ambient mass spectrometry for ultrasensitive analysis of tetrabromobisphenol-A analogs)[J].中国化学快报（英文版）,2022(08):3849-3852

dibromopropyl,MDBPE,MHEE,CFDI,icological

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