典型文献
Chemical identification, antioxidant, cholinesterase inhibitory, and cytotoxic properties of fucoidan extracted from Persian Gulf Sargassum angustifolium
文献摘要：
Marine macroalgal sulfated fucose-containing polysaccharides, like fucoidan, have drawn significant attention due to their biotechnological potentials, such as anti-cancer, antioxidant, and anti-cholinesterase activities. The fucoidan derived from brown macroalgae Sargassum angustifolium species (FSA) was investigated for its cytotoxic effects and alterations in cell proliferation, and cell cycle-related gene expression in the present study occurred on NB4 cell line. The results showed that FSA would induce p53, p21, pro-apoptotic genes and increase expression of the p15 gene as a cell arrest marker. Also, FSA inhibited the anti-apoptotic effect of the Bcl-2 gene and decreased dnmt-1 gene expression. FSA significantly exhibited potent 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (p<0.05) with an IC50 value of 0.157 mg/mL and showed moderate anti-acetylcholinesterase activity with an IC50 value of 1.20 μg/mL. These results indicated the potential of FSA for the development of therapeutic or preventive agents of cancer and Alzheimer's disease mainly through cytotoxic effect and AChE (acetylcholinesterase) inhibition as well as additional antioxidant capacities.
文献关键词：
中图分类号：
作者姓名：
Arghavan Hosseinpouri;Mehdi Mohammadi;Elham Ehsandoost;Paria Sharafi-Badr;Narges Obeidi
作者机构：
Department of Cellular and Molecular Sciences,Faculty of Sciences,Persian Gulf University,Bushehr 75168,Iran;Department of Marine Biotechnology,Persian Gulf Institute,Persian Gulf University,Bushehr 75168,Iran;Department of Biotechnology,Persian Gulf Algae Development Technology,Delvar Industrial Zone No.55,Bushehr 75168,Iran;Department of Food Science and Technology,Shiraz University,Shiraz 71441-65186,Iran;Department of Pharmacognosy and Pharmaceutical Biotechnology,School of Pharmacy,Iran University of Medical Sciences,Tehran 14496-14535,Iran;Department of Hematology,Faculty of Paramedicine,Bushehr University of Medical Sciences,Bushehr 75146-33341,Iran
文献出处：
引用格式：
[1]Arghavan Hosseinpouri;Mehdi Mohammadi;Elham Ehsandoost;Paria Sharafi-Badr;Narges Obeidi-.Chemical identification, antioxidant, cholinesterase inhibitory, and cytotoxic properties of fucoidan extracted from Persian Gulf Sargassum angustifolium)[J].海洋学报（英文版）,2022(12):133-141
A类：
macroalgal,dnmt
B类：
Chemical,identification,antioxidant,inhibitory,cytotoxic,properties,fucoidan,extracted,from,Persian,Gulf,Sargassum,angustifolium,Marine,sulfated,fucose,containing,polysaccharides,like,have,drawn,attention,due,their,biotechnological,potentials,such,cancer,activities,derived,brown,macroalgae,species,FSA,was,investigated,its,effects,alterations,cell,proliferation,cycle,related,expression,present,study,occurred,NB4,results,showed,that,would,induce,p53,p21,apoptotic,genes,increase,p15,arrest,marker,Also,inhibited,Bcl,decreased,significantly,exhibited,diphenyl,picrylhydrazyl,DPPH,radical,scavenging,activity,IC50,value,moderate,acetylcholinesterase,These,indicated,development,therapeutic,preventive,agents,Alzheimer,disease,mainly,through,AChE,inhibition,well,additional,capacities
AB值：
0.582415
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