典型文献
C-type natriuretic peptide stimulates chicken myoblast differentiation through NPRB/NPRC receptors and metabolism pathway
文献摘要：
Skeletal muscle development is closely related with the amount of meat production and its quality in chickens. Natriuretic peptides (NPs) play an important role in myotube formation and fat oxidation of skeletal muscle in animals. The effect of C-type natriuretic peptide (CNP), an important member of the NPs, and its underlying molecular mechanisms in skeletal muscle are incompletely understood. Treatment of myoblasts with CNP led to enhanced proliferation/differentiation and significantly upregulated (P<0.05) mRNA expression of the CNP receptors natriuretic peptide receptor B (NPRB) and the clearance receptor C (NPRC). In cells exposed to CNP, 142 differentially expressed genes (84 up-regulation and 58 down-regulation) (P<0.05) were identified by RNA-sequencing compared with those in control cells. Sixteen genes were significantly enriched (P<0.05) in the metabolic pathway, and six of them (phospholipase C β4, phospholipase C β2, phosphoglycerate mutase 1, creatine kinase B, peroxiredoxin 6 and CD38) were closely related to skeletal muscle development and differentially expressed. In conclusion, CNP stimulated differentiation of myoblasts by upregulating expression of the NPRB and NPRC receptors and enriching key genes in the metabolic pathway.
文献关键词：
中图分类号：
作者姓名：
HUANG Hua-yun;LIANG Zhong;LIU Long-zhou;LI Chun-miao;HUANG Zhen-yang;WANG Qian-bao;LI Shou-feng;ZHAO Zhen-hua
作者机构：
Jiangsu Institute of Poultry Science,Yangzhou 225125,P.R.China;College of Animal Science,Yangtze University,Jingzhou 8060550,P.R.China
文献出处：
引用格式：
[1]HUANG Hua-yun;LIANG Zhong;LIU Long-zhou;LI Chun-miao;HUANG Zhen-yang;WANG Qian-bao;LI Shou-feng;ZHAO Zhen-hua-.C-type natriuretic peptide stimulates chicken myoblast differentiation through NPRB/NPRC receptors and metabolism pathway)[J].农业科学学报（英文）,2022(02):496-503
A类：
NPRB,NPRC,myotube
B类：
type,natriuretic,stimulates,differentiation,through,receptors,metabolism,pathway,Skeletal,muscle,development,closely,related,amount,meat,production,its,quality,chickens,Natriuretic,peptides,NPs,play,important,role,formation,fat,oxidation,skeletal,animals,effect,CNP,member,underlying,molecular,mechanisms,incompletely,understood,Treatment,myoblasts,led,enhanced,proliferation,significantly,upregulated,expression,clearance,In,cells,exposed,differentially,expressed,genes,regulation,down,were,identified,by,sequencing,compared,those,control,Sixteen,enriched,metabolic,six,them,phospholipase,phosphoglycerate,mutase,creatine,kinase,peroxiredoxin,CD38,conclusion,stimulated,upregulating,enriching,key
AB值：
0.500872
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
