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典型文献
Nano-selenium alleviates cadmium-induced cerebellar injury by activating metal regulatory transcription factor 1 mediated metal response
文献摘要:
This study aims to investigate the role of metal regulatory transcription factor 1(MTF1)-mediated metal response in cadmium(Cd)-induced cerebellar injury,and to evaluate the antagonistic effects of nano-selenium(Nano-Se)against Cd toxicity.A total of 80 chicks(1 d old,male,Hy-Line Variety White)were randomly allocated to 4 treatment groups for 3 months:the control group(fed with a basic diet,n=20),the Nano-Se group(basic diet with 1 mg/kg nano-Se 1 mg/kg Nano-Se in basic diet,n=20),the Nano-Se+Cd group(basic diet with 1 mg/kg Nano-Se and 140 mg/kg CdCl2,n=20)and the Cd group(basic diet with 140 mg/kg CdCl2,n=20).The results of the experiment showed that the Purkinje cells were significantly decreased with their degradation and indistinct nucleoli after Cd exposure.Moreover,expo-sure to Cd caused a significant accumulation of Cd and cupper.However,the contents of Se,iron,and zinc were decreased,thereby disturbing the metal homeostasis in the cerebellum.The Cd exposure also resulted in high levels of malondialdehyde(MDA)and down regulation of selenoprotein transcriptome.Furthermore,the expressions of MTF1,metallothionein 1(MT1),MT2,zinc transporter 3(ZNT3),ZNT5,ZNT10,zrt,irt-like protein 8(ZIP8),ZIP10,transferrin(TF),ferroportin 1(FPN1),ATPase copper transporting beta(ATP7B),and copper uptake protein 1(CTR1)were inhibited by Cd exposure.However,all these changes were significantly alleviated by the supplementation of Nano-Se.This study proved that Cd could disorder metal homeostasis and induce oxidative stress,whereas Nano-Se could relieve all these negative effects caused by Cd via activating the MTF1-mediated metal response in the cerebellum of chicken.
文献关键词:
作者姓名:
Shao-Shuai Bi;Milton Talukder;Hai-Tao Jin;Mei-Wei Lv;Jing Ge;Cong Zhang;Jin-Long Li
作者机构:
College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China;College of Biotechnology and Pharmaceutical Engineering of West Anhui University,Lu'an 237012,China;Department of Physiology and Pharmacology,Faculty of Animal Science and Veterinary Medicine,Patuakhali Science and Technology University,Barishal,8210,Bangladesh;Quality and Safety Institute of Agricultural Products,Heilongjiang Academy of Agricultural Sciences,Harbin 150010,China;College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450002,China;Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment,Northeast Agricultural University,Harbin 150030,China;Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine,Northeast Agricultural University,Harbin 150030,China
引用格式:
[1]Shao-Shuai Bi;Milton Talukder;Hai-Tao Jin;Mei-Wei Lv;Jing Ge;Cong Zhang;Jin-Long Li-.Nano-selenium alleviates cadmium-induced cerebellar injury by activating metal regulatory transcription factor 1 mediated metal response)[J].动物营养(英文),2022(04):402-412
A类:
MTF1,Se+Cd,nucleoli,cupper,ZNT3,ZNT5,ZNT10,zrt,irt,ZIP8,ZIP10
B类:
Nano,selenium,alleviates,cadmium,induced,cerebellar,injury,activating,regulatory,transcription,mediated,response,This,study,aims,investigate,role,evaluate,antagonistic,effects,nano,against,toxicity,total,chicks,old,male,Hy,Line,Variety,White,were,randomly,allocated,treatment,groups,months,control,fed,basic,diet,CdCl2,results,experiment,showed,that,Purkinje,cells,significantly,decreased,their,degradation,indistinct,after,exposure,Moreover,caused,accumulation,However,contents,iron,zinc,thereby,disturbing,homeostasis,cerebellum,also,resulted,high,levels,malondialdehyde,down,regulation,selenoprotein,transcriptome,Furthermore,expressions,metallothionein,MT1,MT2,transporter,like,transferrin,ferroportin,FPN1,ATPase,copper,transporting,beta,ATP7B,uptake,CTR1,inhibited,these,changes,alleviated,supplementation,proved,could,disorder,oxidative,stress,whereas,relieve,negative,chicken
AB值:
0.45971
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