典型文献
Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs
文献摘要：
Intestinal microbes are closely associated with host health,depending on metabolic crosstalk between the microbiota and host.Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host;however,our understanding about the influence of intestinal microbiota on host tryptophan metabolism is limited.Thus,we established germ-free(GF)pig models to systemically explore the influence of intestinal microbiota on tryptophan metabolism.Five GF pigs were kept in GF conditions throughout the experiment(GF group).Six GF pigs were transplanted with fecal microbiota from donor sows to act as control pigs.Compared with control pigs,the GF pigs had remarkable alterations in tryptophan metabolism.The differential metabolites(P＜0.05)were mainly found in the liver,circulation system and large intestine.Notably,the alteration of metabolites in tryptophan metabolism varied among organs,especially for the serotonin pathway.In GF pigs,trypto-phan and kynurenine in the large intestine and 5-hydroxytryptophan in most organs were increased(P＜0.05),while metabolites in the indole pathway in most organs were decreased(P＜0.05).Collec-tively,our study reveals changes in tryptophan metabolism in GF pigs,highlighting the critical role of gut microbes in shaping host tryptophan metabolism.
文献关键词：
中图分类号：
作者姓名：
Bingnan Liu;Dongming Yu;Jing Sun;Xiaoyan Wu;Zhongquan Xin;Baichuan Deng;Lijuan Fan;Jian Fu;Liangpeng Ge;Wenkai Ren
作者机构：
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources,Guangdong Laboratory of Lingnan Modern Agriculture,National Engineering Research Center for Breeding Swine Industry,Guangdong Provincial Key Laboratory of Animal Nutrition Control,College of Animal Science,South China Agricultural University,Guangzhou,China;Chongqing Academy of Animal Sciences,Chongqing,China
文献出处：
引用格式：
[1]Bingnan Liu;Dongming Yu;Jing Sun;Xiaoyan Wu;Zhongquan Xin;Baichuan Deng;Lijuan Fan;Jian Fu;Liangpeng Ge;Wenkai Ren-.Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs)[J].动物营养（英文）,2022(04):190-200
A类：
trypto,phan,Collec
B类：
Characterizing,influence,gut,microbiota,host,metabolism,germ,free,pigs,Intestinal,microbes,closely,associated,health,depending,metabolic,crosstalk,between,Tryptophan,one,best,examples,intestinal,however,our,understanding,about,limited,Thus,established,GF,models,systemically,explore,Five,were,kept,conditions,throughout,experiment,group,Six,transplanted,fecal,from,donor,sows,control,Compared,had,remarkable,alterations,differential,metabolites,mainly,found,liver,circulation,large,intestine,Notably,varied,among,organs,especially,serotonin,pathway,kynurenine,hydroxytryptophan,most,increased,while,indole,decreased,tively,study,reveals,changes,highlighting,critical,role,shaping
AB值：
0.448763
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