典型文献
Dietary supplementation of sulfur amino acids improves intestinal immunity to Eimeria in broilers treated with anti-interleukin-10 antibody
文献摘要:
Oral antibody to interleukin-10(anti-IL-10)enhances the intestinal immune defense against Eimeria.The sulfur amino acids methionine and cysteine(M+C)play essential roles in inducing and maintaining protective immune responses during intestinal infections.Hence,increased dietary M+C may support the anti-IL-10-induced intestinal immunity to Eimeria.Broilers(n=640)were arranged in a 2×2×2 factorial design with 2 levels of each of the 3 main factors:dietary standardized ileal digestible(SID)M+C levels(0.6%or 0.8%),dietary anti-IL-10 supplementation(with or without),and coccidiosis chal-lenge(control or challenge).Briefly,the broilers were supplied with either 0.6%or 0.8%SID M+C,each with or without anti-IL-10(300 μg/kg),from d 10 to 21.On d 14,broilers from each diet were gavaged with either PBS or Eimeria.The resulting Eimeria infection induced fecal oocyst shedding and intestinal lesions.Broilers fed 0.8%SID M+C(main effects,P≤0.05)had decreased feed-to-gain ratio,increased duodenum and cecum luminal anti-Eimeria IgA titers,and decreased fecal oocyst counts,when compared to 0.6%SID M+C.The supplementation of anti-IL-10(main effects,P≤0.05)increased cecum luminal total IgA concentration and decreased cecum lesions.Interactions(P≤0.05)were detected for growth performance and cecum luminal IFN-γ.Briefly,the highest body weight gain and feed intake were reached in PBS-gavaged broilers fed 0.8%SID M+C with no anti-IL-10 and in Eimeria-challenged broilers fed 0.8%SID M+C with anti-IL-10.In Eimeria-infected broilers,anti-IL-10 increased intestinal luminal IFN-γ and body weight gain only at 0.8%SID M+C.Collectively,anti-IL-10 increased intestinal luminal IFN-γ levels,decreased cecum lesions and restored growth only when fed with adequate amounts of sulfur amino acids.Our findings underscore the importance of providing sufficient essential nutrients to support the anti-IL-10 induced immunity against coccidiosis.
文献关键词:
中图分类号:
作者姓名:
Zhouzheng Ren;Jiakun Yan;Rose Whelan;Xujie Liao;Daniel E.Bütz;Maria K.Arendt;Mark E.Cook;Xiaojun Yang;Thomas D.Crenshaw
作者机构:
College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi,China;Department of Animal Sciences,University of Wisconsin,Madison,WI,USA;Evonik Operations GmbH,Hanau-Wolfgang,Germany
文献出处:
引用格式:
[1]Zhouzheng Ren;Jiakun Yan;Rose Whelan;Xujie Liao;Daniel E.Bütz;Maria K.Arendt;Mark E.Cook;Xiaojun Yang;Thomas D.Crenshaw-.Dietary supplementation of sulfur amino acids improves intestinal immunity to Eimeria in broilers treated with anti-interleukin-10 antibody)[J].动物营养(英文),2022(03):382-389
A类:
M+C,Broilers,coccidiosis,oocyst
B类:
Dietary,supplementation,sulfur,amino,acids,improves,intestinal,immunity,Eimeria,broilers,treated,interleukin,antibody,Oral,enhances,immune,defense,against,methionine,cysteine,play,essential,roles,inducing,maintaining,protective,responses,during,infections,Hence,increased,dietary,may,support,induced,were,arranged,factorial,design,levels,factors,standardized,ileal,digestible,SID,without,control,Briefly,supplied,either,from,On,gavaged,PBS,resulting,fecal,shedding,lesions,fed,effects,had,decreased,feed,duodenum,cecum,luminal,IgA,titers,counts,when,compared,total,concentration,Interactions,detected,growth,performance,IFN,highest,weight,intake,reached,challenged,infected,only,Collectively,restored,adequate,amounts,Our,findings,underscore,importance,providing,sufficient,nutrients
AB值:
0.352392
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