典型文献
Dietary vitamin D3 deprivation suppresses fibroblast growth factor 23 signals by reducing serum phosphorus levels in laying hens
文献摘要：
The present study was carried out to evaluate the effect of dietary supplemental vitamin D3 on fibroblast growth factor 23(FGF23)signals as well as phosphorus homeostasis and metabolism in laying hens.Fourteen 40-week-old Hy-Line Brown layers were randomly assigned into 2 treatments:1)vitamin D3 restriction group(n=7)fed 0 IU/kg vitamin D3 diet,and 2)regular vitamin D3 group(n=7)fed 1,600 IU/kg vitamin D3 diet.The study lasted for 21 d.Serum parameters,phosphorus and calcium excretion status,and tissue expressions of type Ⅱ sodium-phosphate co-transporters(NPt2),FGF23 signals and vitamin D3 metabolic regulators were determined.Hens fed the vitamin D3 restricted diet had decreased serum phosphorus levels(by 31.3％,P=0.028)when compared to those fed regular vitamin D3 diet.In response to the decreased serum phosphorus,the vitamin D3 restricted laying hens exhibited:1)sup-pressed kidney expressions of 25-hydroxyvitamin D 1-α-hydroxylase(CYP27B1,by 52.8％,P=0.036)and 1,25-dihydroxyvitamin D 24-hydroxylase(CYP24A1,by 99.4％,P=0.032);2)suppressed serum levels of FGF23(by 14.6％,P=0.048)and increased serum alkaline phosphatase level(by 414.1％,P=0.012);3)decreased calvaria mRNA expressions of fibroblast growth factor receptors(FGFR1,by 85.2％,P=0.003,FGFR2,by 89.4％,P=0.014,FGFR3,by 88.8％,P=0.017,FGFR4,by 89.6％,P=0.030);4)decreased kidney mRNA expressions of FGFR1(by 65.5％,P=0.021),FGFR4(by 66.0％,P=0.050)and KLOTHO(by 68.8％,P=0.038);5)decreased kidney protein expression of type 2a sodium-phosphorus co-transporters(by 54.3％,P=0.039);and 6)increased percent excreta calcium(by 26.9％,P=0.002).In conclusion,the deprivation of dietary vitamin D3 decreased FGF23 signals in laying hens by reducing serum FGF23 level and suppressing calvaria and kidney mRNA expressions of FGF23 receptors.
文献关键词：
中图分类号：
作者姓名：
Jiakun Yan;Chong Pan;Yanli Liu;Xujie Liao;Jionghao Chen;Yufei Zhu;Xinhuo Huang;Xiaojun Yang;Zhouzheng Ren
作者机构：
College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi,China;Nano Vitamin Engineering Research Center of Shaanxi Province,Xi'an,China
文献出处：
引用格式：
[1]Jiakun Yan;Chong Pan;Yanli Liu;Xujie Liao;Jionghao Chen;Yufei Zhu;Xinhuo Huang;Xiaojun Yang;Zhouzheng Ren-.Dietary vitamin D3 deprivation suppresses fibroblast growth factor 23 signals by reducing serum phosphorus levels in laying hens)[J].动物营养（英文）,2022(02):23-30
A类：
NPt2,Hens,calvaria,KLOTHO,excreta
B类：
Dietary,D3,deprivation,suppresses,fibroblast,growth,signals,by,reducing,serum,phosphorus,levels,laying,hens,present,study,was,carried,out,evaluate,effect,dietary,supplemental,FGF23,well,homeostasis,metabolism,Fourteen,week,old,Hy,Line,Brown,layers,were,randomly,assigned,into,treatments,restriction,group,fed,IU,regular,lasted,Serum,parameters,calcium,excretion,status,tissue,expressions,type,sodium,phosphate,transporters,metabolic,regulators,determined,restricted,had,decreased,when,compared,those,In,response,exhibited,kidney,hydroxylase,CYP27B1,dihydroxyvitamin,CYP24A1,suppressed,increased,alkaline,phosphatase,receptors,FGFR1,FGFR2,FGFR3,FGFR4,protein,2a,percent,conclusion,suppressing
AB值：
0.394032
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
