The objective of this study was to determine the effect of dietary supplementation of β-hydroxybutyric acid(BHBA)on performance,nutrient digestibility,organ development,and serum composition in early-weaned goat kids.Sixty-four goat kids at 30 d of age were assigned to 4 treatments in a completely randomized design:1)control(basal diet);2)low(basal diet with 3 g/d per animal BHBA);3)medium(basal diet with 6 g/d per animal BHBA;and 4)high(basal diet with 9 g/d per animal BHBA).Subse-quently,48(6 kids per treatment)goat kids were randomly selected and slaughtered at 60 and 90 d of age.Compared with the control group,BHBA at low and high doses increased body weight(P＜0.05),average daily gain(P＜0.01),and average daily starter intake(P＜0.01).The BHBA improved organ development,especially at the lowest dose(P＜0.01).The digestibility of dry matter and crude protein increased with age(P＜0.05).However,BHBA did not affect nutrient digestibility.Compared with the control group,serum ceruloplasmin increased(P＜0.05)with high BHBA level at 90 d of age.However,the serum creatinine(P＜0.05)increased over time but was not affected by BHBA.The serum total antioxidant capacity and superoxide dismutase decreased with the high dose of BHBA at 90 d of age(P＜0.01).In contrast,the serum glutathione peroxidase and malondialdehyde increased with the high doses of BHBA(P＜0.01).Overall,low doses of BHBA were positive for growth performance,organ development,and health status against weaning stress.Whereas high doses of BHBA in the long term could negatively affect antioxidant status.

Mahmoud M.Abdelsattar;Einar Vargas-Bello-Pérez;Yimin Zhuang;Yuze Fu;Naifeng Zhang

Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs,Institute of Feed Research of Chinese Academy of Agricultural Sciences,Beijing,100081,China;Department of Animal and Poultry Production,Faculty of Agriculture,South Valley University,Qena,83523,Egypt;Department of Veterinary and Animal Sciences,Faculty of Health and Medical Sciences,University of Copenhagen,Gr?nnegardsvej 3,Frederiksberg C,DK-1870,Denmark

动物营养（英文）

[1]Mahmoud M.Abdelsattar;Einar Vargas-Bello-Pérez;Yimin Zhuang;Yuze Fu;Naifeng Zhang-.Impact of dietary supplementation of β-hydroxybutyric acid on performance,nutrient digestibility,organ development and serum stress indicators in early-weaned goat kids)[J].动物营养（英文）,2022(02):16-22

hydroxybutyric

Impact,dietary,supplementation,acid,performance,nutrient,digestibility,organ,development,serum,stress,indicators,early,weaned,goat,kids,objective,this,study,was,determine,effect,BHBA,composition,Sixty,four,were,assigned,treatments,completely,randomized,design,control,basal,animal,medium,high,Subse,quently,randomly,selected,slaughtered,Compared,group,doses,increased,body,weight,average,daily,starter,intake,improved,especially,lowest,dry,matter,crude,protein,However,did,not,ceruloplasmin,level,creatinine,over,affected,by,total,antioxidant,capacity,superoxide,dismutase,decreased,In,contrast,glutathione,peroxidase,malondialdehyde,Overall,positive,growth,health,status,against,weaning,Whereas,long,could,negatively

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